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TranscriptomicsMKL1-dependent tenascin-C transcription
The aim of the experiment is to investigate whether megakaryoblastic leukemia factor-1 (MKL1) induces tenascin-C in normal mammary epithelial HC11 and tumor mammary epithelial 4T1 cell lines, as well as to identify other genes that are transcriptionally regulated by MKL1. For this purpose, we compar...
ORGANISM(S): Mus musculus 
2011-06-10 | E-MEXP-3232 | biostudies-arrayexpress
TranscriptomicsIdentification of megakaryoblastic leukemia-1 (Mkl1) target genes in 4T1 mammary carcinoma cells
The present study was designed to identify Mkl1 target genes whose expression requires either the B1 site of Mkl1 and serum response factor (SRF), respectively, or the SAP domain of Mkl1. For this purpose, we obtained the transcriptomes of four stable 4T1 cell lines that either overexpress full leng...
ORGANISM(S): Mus musculus 
2016-07-15 | E-GEOD-59459 | biostudies-arrayexpress
ProteomicsSmoothened Transduces Hedgehog Signals via Activity-Dependent Sequestration of PKA Catalytic Subunits
The Hedgehog (Hh) pathway is essential for organ development, homeostasis, and regeneration. Dysfunction of this cascade drives several cancers. To control expression of pathway target genes, the G protein-coupled receptor (GPCR) Smoothened (SMO) activates glioma-associated (GLI) transcription facto...
ORGANISM(S): Homo Sapiens 
PXD023893 | panorama
ProteomicsPeptidomic analysis of pancreatic neurodendocrine tumours (Glucagonoma)
A peptidomic analysis of plasma from patients with well characterised pancreatic neuroendocrine tumours (PNET) was performed. A nano LC-MS analysis identified a number of peptides from the glucagon gene, which were idenfiried in a previous case study using multiple immunoassays. Peptides to other pr...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-08-31 | MSV000082880 | MassIVE
ProteomicsProfiling the diversity of agonist-selective effects on the proximal proteome environment of G protein-coupled receptors
G-protein coupled receptors (GPCRs) regulate various aspects of cellular behavior and represent actionable targets for drug discovery. Activation of specific signaling pathways downstream of G-protein coupled receptors (GPCRs) or targeting the receptors at selected cellular locations has the potenti...
ORGANISM(S): Homo Sapiens 
2024-03-31 | PXD031393 | panorama
GenomicsAssociation studies using the Metabochip array - Samples analysed by the WTCCC (1958 British Birth Cohort (58BC), Hypertension cohort (HT), Type 2 Diabetes Cohort (T2D) and Coronary Artery Disease (CAD) cohort)
Genomewide association studies (GWAS) have proven a powerful hypothesis-free method to identify common disease-associated variants. Even quite large GWAS, however, have only at best identified moderate proportions of the genetic variants contributing to disease heritability. To provide cost-effectiv...
EGAS00000000115 | EGA
TranscriptomicsMicroRNAs of the RPE are essential for RPE differentiation and photoreceptor maturation (mRNA)
Dysfunction of the retinal pigmented epithelium (RPE) results in degeneration of photoreceptors and vision loss and is correlated with common blinding disorders in humans. Although many protein-coding genes are known to be expressed in RPEs and important for their development and maintenance, virtua...
ORGANISM(S): Mus musculus 
2015-06-16 | E-GEOD-69881 | biostudies-arrayexpress
TranscriptomicsMicroRNAs of the RPE are essential for RPE differentiation and photoreceptor maturation (microRNA)
Dysfunction of the retinal pigmented epithelium (RPE) results in degeneration of photoreceptors and vision loss and is correlated with common blinding disorders in humans. Although many protein-coding genes are known to be expressed in RPEs and important for their development and maintenance, virtua...
ORGANISM(S): Mus musculus 
2015-06-16 | E-GEOD-69882 | biostudies-arrayexpress
GenomicsCAD - samples
WTCCC2 samples from Coronary Artery Disease Cohort
EGAD00010000236 | EGA
Genomics58BC - samples
WTCCC2 samples from 1958 British Birth Cohort
EGAD00010000234 | EGA
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