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MetabolomicsER stress inhibits liver fatty acid oxidation while unmitigated stress leads to anorexia-induced lipolysis and both liver and kidney steatosis
The unfolded protein response (UPR), induced by endoplasmic reticulum (ER) stress, regulates the expression of factors that restore protein folding homeostasis. However, in the liver and kidney, ER stress also leads to lipid accumulation, accompanied at least in the liver by transcriptional suppress...
2017-06-23 | MTBLS472 | MetaboLights
TranscriptomicsWide-spread disruption of transcription termination in HSV-1 infection: Next generation sequencing of total and newly transcribed (4sU-RNA) RNA
Primary human foreskin fibroblasts (HFF) were infected with wild-type simplex virus 1 (HSV-1) strain 17 at a multiplicity of infection (MOI) of 10. Newly transcribed RNA was labelled by adding 500µM 4-thiouridine (4sU) to the cell culture media for 1h. Total cellular RNA was isolated using Trizol. N...
ORGANISM(S): Homo sapiens 
2015-05-26 | E-GEOD-59717 | biostudies-arrayexpress
TranscriptomicsWide-spread disruption of transcription termination in HSV-1 infection: Next-generation sequencing of translational activityd by ribosome profiling
Primary human foreskin fibroblasts (HFF) were infected with wild-type simplex virus 1 (HSV-1) strain 17 at a multiplicity of infection (MOI) of 10. Ribosome profiling was performed at various times during infection with minor modification to the protocol described in Stern-Ginossar N et al., Science...
ORGANISM(S): Homo sapiens 
2015-05-26 | E-GEOD-60040 | biostudies-arrayexpress
UnknownStereotactic radiotherapy for soft tissue and bone sarcomas: real-world evidence.
Not available
S-EPMC8848098 | biostudies-literature
UnknownThe Role of Macrophages in Sarcoma Tumor Microenvironment and Treatment.
Not available
S-EPMC10648209 | biostudies-literature
TranscriptomicsMetastatic potential is determined early in synovial sarcoma development and reflected by tumor molecular features [transcriptome]
Synovial sarcoma (SynSa) is an aggressive mesenchymal tumor, comprising approximately 10% of all soft tissue sarcomas. Over half of SynSa patients develop metastasis or local recurrence, but the underlying molecular mechanisms of the aggressive clinical behavior remain poorly characterized. Sixty f...
ORGANISM(S): Homo sapiens 
2014-07-31 | E-GEOD-54187 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human Schwann cells FROM HMSN1A, HMSN-LOM AND congenital cateracts facial dysmophism neuropathy (CCFDN) syndrome TO identify down-stream effects IN demyelinating neuropathies
Hereditary Motor and Sensory Neuropathies (HMSN) are the most common inherited peripheral neuropathies and comprise a group of genetically heterogeneous diseases. We study the genetic defects causing three demyelinating disorders: HMSN1A, HMSN-LOM and congenital cateracts facial dysmophism neuropath...
ORGANISM(S): Homo sapiens 
2008-04-05 | E-GEOD-7423 | biostudies-arrayexpress
UnknownCopper Chalcogenide-Copper Tetrahedrite Composites-A New Concept for Stable Thermoelectric Materials Based on the Chalcogenide System.
Not available
S-EPMC8157852 | biostudies-literature
UnknownEfficacy and Safety Outcomes in Patients With Advanced Melanoma Who Discontinued Treatment With Nivolumab and Ipilimumab Because of Adverse Events: A Pooled Analysis of Randomized Phase II and III Trials.
Not available
S-EPMC5791828 | biostudies-literature
UnknownHydrodynamic electrospray ionization jetting of calcium alginate particles: effect of spray-mode, spraying distance and concentration.
Not available
S-EPMC9082322 | biostudies-literature
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