Sort   by:  
 Page size 
TranscriptomicsTestis-expressed cluster of microRNAs 959-964 controls spermatid differentiation in Drosophila melanogaster
MicroRNAs are a wide class of ~22 nt non-coding RNAs of metazoans capable of inhibiting target mRNAs translation by binding to partially complementary sites in their 3’UTRs. Due to their regulatory potential, miRNAs are implicated in functioning of a broad range of biological pathways and processe...
ORGANISM(S): Drosophila melanogaster 
2015-10-29 | E-MTAB-3214 | biostudies-arrayexpress
TranscriptomicsEuchromatic transposon insertions trigger production of novel pi- and endo-siRNAs at the target sites in the Drosophila germline
The control of transposable element (TE) activity in germ cells provides genome integrity over generations. A distinct small RNA-mediated pathway utilizing Piwi-interacting RNAs (piRNAs) suppresses TE expression in gonads of metazoans. In the fly, primary piRNAs derive from so-called piRNA clusters,...
ORGANISM(S): Drosophila melanogaster 
2014-02-07 | E-GEOD-46105 | biostudies-arrayexpress
TranscriptomicsDe novo piRNA cluster formation in the Drosophila germline triggered by transgenes containing a transcribed transposon fragment
PIWI interacting RNAs (piRNAs) provide defense against transposable element (TE) expansion in the germline of metazoans. piRNAs are processed from the transcripts encoded by specialized heterochromatic clusters enriched in damaged copies of transposons. How these regions are recognized as a source o...
ORGANISM(S): Drosophila melanogaster 
2013-04-25 | E-GEOD-41780 | biostudies-arrayexpress
Sort   by:  
 Page size