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TranscriptomicsExpression profiling of HeLa cells at S and G2/M phases of mitotic cell cycle.
We compared the mRNAs expression profile of HeLa cells between two phases of the mitotic cell cycle: S and G2/M phases. Results provide insight into the regulation of transcript levels during mitotic cell cycle progression. HeLa cells were synchronized with double thymidine blockade (12 hours with ...
ORGANISM(S): Homo sapiens 
2010-05-07 | E-GEOD-15547 | biostudies-arrayexpress
TranscriptomicsGlobal analysis of differential polyadenylation of mRNAs during mitotic cell cycle: S phase versus G2/M phase.
We compared the poly(A) tail length status of mRNAs of HeLa cells between two phases of the mitotic cell cycle: S and G2/M phases. Hundreds of mRNAs were found to be regulated by changes in their poly(A) tail length during mitotic cell cycle in a phase specific manner. Many of these differentially p...
ORGANISM(S): Homo sapiens 
2010-05-07 | E-GEOD-15399 | biostudies-arrayexpress
TranscriptomicsExpression profiling of HeLa cells at S and G2/M phases of mitotic cell cycle.
We compared the mRNAs expression profile of HeLa cells between two phases of the mitotic cell cycle: S and G2/M phases. Results provide insight into the regulation of transcript levels during mitotic cell cycle progression. HeLa cells were synchronized with double thymidine blockade (12 hours with 2...
ORGANISM(S): Homo sapiens 
2010-04-01 | GSE15547 | GEO
TranscriptomicsHCT 116 cells expressing Fucci (fluorescent ubiquitination-based cell cycle indicator); G1 phase vs. S/G2/M phase
Fucci-expressing HCT116 were inoculated into subcutaneous tissue or cecum of NOD/SCID mice. Four weeks after inoculation, Fucci green (mAG; S/G2/M) and red (mKO2;G1) expressing cells were isolated from implanted tumors by FACSAria sorting (BD, Biosciences). Comparative analyses among green and red c...
ORGANISM(S): Homo sapiens 
2014-01-09 | E-GEOD-34940 | biostudies-arrayexpress
TranscriptomicsGene expression changes induced by Benzo[a]pyrene (BaP) in human breast carcinoma cell line MCF-7 in different phases of the cell cycle
Benzo[a]pyrene (BaP) is a widespread environmental genotoxic carcinogen that damages DNA by forming adducts. This damage with along the activation of the aryl hydrocarbon receptor (AHR) induces complex transcriptional responses in cells. To investigate whether human cells are more susceptible to BaP...
ORGANISM(S): Homo sapiens 
2012-02-02 | E-GEOD-26917 | biostudies-arrayexpress
GenomicsRPA accumulation during class switch recombination represents 5'-3' DNA end resection during the S-G2/M phase of the cell cycle
AID promotes chromosomal translocations by inducing DNA double-strand breaks (DSBs) at immunoglobulin (Ig) genes and oncogenes in G1. RPA is a ssDNA-binding protein that associates with resected DSBs in the S phase and facilitates the assembly of factors involved in homologous repair (HR) such as Ra...
ORGANISM(S): Mus musculus 
2013-01-02 | GSE42451 | GEO
TranscriptomicsTranscription profiling of S. pombe reveals Cyclin dependent kinase inhibits re-initiation of a normal S-phase program during G2
To achieve faithful replication of the genome once in each cell cycle, re-initiation of S-phase is prevented in G2 and origins are restricted from re-firing within S-phase. We have investigated the block to re-replication during G2 in fission yeast. The DNA synthesis that occurs when G2/M cyclin d...
ORGANISM(S): Schizosaccharomyces pombe 
2009-05-13 | E-MTAB-105 | biostudies-arrayexpress
UnknownE2Fs link the control of G1/S and G2/M transcription.
Not available
S-EPMC533046 | biostudies-literature
UnknownRB, p130 and p107 differentially repress G1/S and G2/M genes after p53 activation.
Not available
S-EPMC6868438 | biostudies-literature
UnknownRepair of G1 induced DNA double-strand breaks in S-G2/M by alternative NHEJ.
Not available
S-EPMC7567796 | biostudies-literature
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