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ProteomicsProteome analysis of Staphylococcus aureus strains
Cervimycins A‒D are natural products of Streptomyces tendae HKI 0179 with promising activity against multidrug resistant staphylococci and vancomycin resistant enterococci. To initiate mode of action studies, we selected cervimycin C and D resistant (CmR) Staphylococcus aureus strains. Genome sequen...
ORGANISM(S): Bacteria Staphylococcus aureus 
2022-09-22 | PXD034970 | Pride
Revertant Antibiotic treatment S. aureus Resistance Mutant Antibiotic 
ProteomicsWhole proteome and Secretome analysis of Staphylococcus aureus ClpXP mutant strains
Staphylococcus aureus represents an opportunistic pathogen which utilizes elaborate quorum sensing mechanisms to precisely control the expression and secretion of virulence factors. Previous studies indicated a role of the ClpXP proteolytic system in controlling pathogenesis. While detailed transcri...
ORGANISM(S): Bacteria Staphylococcus aureus 
2021-03-12 | PXD018932 | Pride
Proteomics Staphylococcus aureus Whole proteome analysis Lc-ms/ms 
ProteomicsStructure of Staphylococcus aureus ClpP bound to the covalent active site inhibitor Cystargolide A
The caseinolytic protease is a highly conserved serine protease, seminal in prokaryotic and eukaryotic protein homeostasis and regulatory proteolysis, and a promising antibacterial and anticancer drug target. Here, we describe the cystargolides as potent and the first natural β-lactone inhibitors of...
ORGANISM(S): Staphylococcus aureus 
2023-11-30 | PXD045453 | Pride
Antibacterials Chemmical proteomics Proteases 
ProteomicsImipridones cause cellular toxicity in human cells and bacteria by ectopic activation of the ClpP protease
Ectopic activation of the conserved ClpP protease by chemical activators causes toxicity in bacteria and human cells due to unrestrained proteolysis. The imipridone ONC201 has been ascribed multiple mechanisms of action and is currently in cancer clinical trials. To systematically investigate the ge...
ORGANISM(S): Homo sapiens (Human) Staphylococcus aureus 
2020-03-26 | PXD016119 | Pride
Imipridones Clpp protease 
ProteomicsA quantitative map of beta-lactone induced virulence regulation
Beta-lactones have recently been introduced as the first selective ClpP inhibitors that attenuate virulence of both sensitive Staphylococcus aureus and multiresistant strains (MRSA). Although previous knockout studies showed that ClpP is essential for S. aureus alpha-toxin production a link between ...
ORGANISM(S): Staphylococcus aureus 
2017-02-08 | PXD004680 | Pride
Proteomics Chemical knockout S. aureus clpp Antivirulence Activity-based protein profiling 
ProteomicsDual effect of Staphylococcus epidermidis DnaK on Staphylococcus aureus biofilm proteostasis and regulation
Staphylococcus aureus and Staphylococcus epidermidis, two Gram-positive bacteria commonly found in the human skin microbiota, form biofilms that contribute to skin dysbiosis and play a key role in conditions like acne and atopic dermatitis. The Calcitonin Gene-Related Peptide (CGRP) is a human pepti...
ORGANISM(S): Staphylococcus aureus 
2026-03-09 | PXD062742 | Pride
Dnak  biofilm  staphylococcus epidermidis  staphylococcus aureus  skin microbiota 
UnknownQuercetin Reduces the Virulence of S. aureus by Targeting ClpP to Protect Mice from MRSA-Induced Lethal Pneumonia.
Not available
S-EPMC9045277 | biostudies-literature
OtherTn-seq of Staphylococcus aureus exposed to Calprotectin
The host protein calprotectin inhibits the growth of a variety of bacterial pathogens through metal sequestration in a process known as 'nutritional immunity'. Staphylococcus aureus growth is inhibited by calprotectin in vitro and calprotectin is localized in vivo to staphylococcal abscesses during ...
ORGANISM(S): Staphylococcus aureus 
2024-05-14 | GSE266003 | GEO
TranscriptomicsThe coordinated adaptation of Staphylococcus aureus to calprotectin dependent metal sequestration [RNA-Seq]
The host protein calprotectin inhibits the growth of a variety of bacterial pathogens through metal sequestration in a process known as 'nutritional immunity'. Staphylococcus aureus growth is inhibited by calprotectin in vitro and calprotectin is localized in vivo to staphylococcal abscesses during ...
ORGANISM(S): Staphylococcus aureus 
2024-05-14 | GSE265954 | GEO
TranscriptomicsCervimycin resistant Staphylococcus aureus strains display a vancomycin intermediate resistant phenotype
Resistance to antibiotics is an emerging problem and necessitates novel antibacterial therapies. Cervimycins A‒D are natural products of Streptomyces tendae HKI 0179 with promising activity against multidrug resistant staphylococci and vancomycin resistant enterococci. We studied the mode of action ...
ORGANISM(S): Staphylococcus aureus 
2022-09-08 | GSE206309 | GEO
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