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TranscriptomicsS1P lyase deficiency disrupts lipid homeostasis in liver
The cleavage of sphingoid base phosphates by sphingosine-1-phosphate (S1P) lyase to produce phosphoethanolamine and a fatty aldehyde is the final degradative step in the sphingolipid metabolic pathway. We have studied mice with an inactive S1P lyase gene and have found that, in addition to the expec...
ORGANISM(S): Mus musculus 
2010-02-05 | E-GEOD-18745 | biostudies-arrayexpress
ProteomicsHuman LC-MS/MS for MBTPS1/S1P protein
To explore the molecular mechanism underlying the inflammatory symptoms, we set out to screen S1P interactors using Co-IP and liquid chromatography-tandem mass spectrometry (LC-MS/MS) and identified 29 potential candidates
ORGANISM(S): Homo sapiens (Human) 
2022-05-04 | PXD031064 | Pride
Human lc-ms/ms 
TranscriptomicsTranscription profiling of human male embryonic stem cell line line grown in standard conditions, with feeder cells and treated with the signalling sphingolipid sphingosine-1-phosphate reveals S1P mediates key targets associated with survival, proliferation and pluripotency
Human embryonic stem cells (hESCs) replicate by the process of self-renewal, whilst maintaining their pluripotency. Understanding the pathways involved in the regulation of this self-renewal process will assist in developing fully-defined conditions for the proliferation of hESCS required for the...
ORGANISM(S): Homo sapiens 
2009-04-30 | E-GEOD-7896 | biostudies-arrayexpress
TranscriptomicsSphingosine-1-phosphate phosphatase 1 regulates keratinocyte differentiation and epidermal homeostasis
Sphingosine 1-phosphate (S1P) is a bioactive lipid whose levels are tightly regulated by its synthesis and degradation. Intracellularly, S1P is dephosphoryled by the actions of two S1P-specific phosphatases, sphingosine 1-phosphate phosphatase 1 and 2. To identify the physiologic functions of S1P p...
ORGANISM(S): Mus musculus 
2013-08-09 | E-GEOD-40368 | biostudies-arrayexpress
TranscriptomicsExpression profiling of human mesoangioblasts indicates that S1P induces differentiation towards smooth muscle cells
cDNA microarray study of human mesoangioblasts treated with 1 µM sphingosine 1-phosphate (S1P) at 6 and 24 h. Agilent whole human genome oligonucleotide microarrays (44 K) were used to examine alterations in gene expression of cells after S1P treatment
ORGANISM(S): Homo sapiens 
2011-05-01 | E-GEOD-17596 | biostudies-arrayexpress
TranscriptomicsSphingosine-1-phosphate Phosphatase 2 Regulates Pancreatic Islet B-cell Endoplasmic Reticulum Stress and Proliferation
Sphingosine-1-phosphate (S1P) is a sphingolipid metabolite that regulates basic cell functions through metabolic and signaling pathways. Intracellular metabolism of S1P is controlled, in part, by two homologous S1P phosphatases, 1 and 2, which are encoded by Sgpp1 and Sgpp2, respectively. S1P phosph...
ORGANISM(S): Mus musculus 
2016-07-25 | E-GEOD-73131 | biostudies-arrayexpress
TranscriptomicsSphingosine-1-phosphate induces pro-remodelling response in airway smooth muscle cells
Background: Increased proliferation of airway smooth muscle (ASM) cells leading to hyperplasia and increased ASM mass is one of the most characteristic features of airway remodelling in asthma. A bioactive lipid, sphingosine-1-phosphate (S1P), has been suggested to affect airway remodelling by stimu...
ORGANISM(S): Homo sapiens 
2015-06-18 | E-GEOD-58657 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human glioblastoma cell line treated with sphingosine 1-phosphate vs. epidermal growth factor identifies 72 genes that are significantly differentially expressed as a unique response to S1P
To gain new insights in the effect of S1P on angiogenesis and invasion of this type of malignant tumor, we used microarrays to investigate the gene expression in glioblastoma as a response to S1P administration in vitro. We compared the expression profiles for the same cell lines under the influence...
ORGANISM(S): Homo sapiens 
2007-10-26 | E-GEOD-4817 | biostudies-arrayexpress
GenomicsEffect of S1P on gene expression in human primary keratinocytes
Effect of S1P on gene expression in human primary keratinocytes
PRJNA957274 | ENA
GenomicsInflammatory monocyte-derived S1P in the lymph node regulates immune response
Inflammatory monocyte-derived S1P in the lymph node regulates immune response
PRJNA578056 | ENA
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