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Natural products have been a great source for novel drugs especially antibiotics. Given the current antibiotic crisis, revisiting poorly characterized antibacterial natural products may reveal novel modes of action (MoA) as inspiration for drug development. Here, we selected the natural product clas...
ORGANISM(S): Escherichia coli 
2026-05-25 | PXD070366 | Pride
Isonitrile natural products exhibit promising antibacterial activities, however, their mode of action (MoA) remains largely unknown. Based on the nanomolar potency of xanthocillin X (Xan) against diverse difficult-to-treat Gram-negative bacteria, including the critical priority pathogen Acinetobacte...
ORGANISM(S): Acinetobacter baumannii ATCC 19606 = CIP 70.34 = JCM 6841 Escherichia coli 
2021-09-09 | PXD021400 | Pride
Metronidazole (Metro) represents the front line-drug against Helicobacter pylori infections, but despite its crucial role as an antibiotic, little is known about its exact mode of action (MoA). To unravel cellular protein targets, we here performed activity-based protein profiling (ABPP) with tailor...
ORGANISM(S): Helicobacter pylori 26695 
2026-04-13 | PXD051773 | Pride
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