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MetabolomicsTo explore the role of circulating oxidized lipids in the progression and prognosis of SA-AKI by means of histochemistry

Background: Plasma oxidized lipids are intimately linked to immune regulation as bioactive mediators. However, it is not clear whether they are related to the progression of sepsis-associated acute kidney injury (SA-AKI) and the effect of continuous renal replacement therapy (CRR...

2024-12-16 | MTBLS11695 | MetaboLights
ProteomicsComprehensive Landscape of SA-AKI Revealed by Integrated Proteomics and Metabolomics Analysis
Sepsis-associated acute kidney injury (SA-AKI) is a severe and life-threatening condi-tion with high morbidity and mortality among emergency patients, and it poses a sig-nificant risk of chronic renal failure. Clinical treatments for SA-AKI remain reactive and non-specific, lacking effective diagnos...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-24 | PXD044371 | Pride
Sa-aki  proteomics  metabolomics  biomarker  mitochondrial dysfunction 
UnknownMultidimensional Landscape of SA-AKI Revealed by Integrated Proteomics and Metabolomics Analysis.
Not available
S-EPMC10526551 | biostudies-literature
UnknownBiomarkers of cell cycle arrest, microcirculation dysfunction, and inflammation in the prediction of SA-AKI.
Not available
S-EPMC11889128 | biostudies-literature
ProteomicsSAA1 delivered by tubular epithelial cell-derived extracellular vesicles aggravate sepsis-associated acute kidney injury by promoting NET formation
Sepsis-associated acute kidney injury (SA-AKI) is highly lethal with a rapid onset, and effective drugs for treatment are lack due to the molecular pathogenesis underlying SA-AKI remains elusive. Tubular epithelial cells (TECs) have increasingly been recognized as a driving force in the progression ...
ORGANISM(S): Mus Musculus 
2024-08-22 | PXD055037 |
UnknownEfficacy of hybrid blood purification for SA-AKI subtypes identified by CCL14: study protocol for a single-centre randomized controlled clinical trial.
Not available
S-EPMC12382114 | biostudies-literature
GenomicsSepsis-associated acute kidney injury in mice and humans elicits heterogeneous renal microvascular microRNA responses
Microvascular endothelial cells play important roles in sepsis-associated acute kidney injury (SA-AKI). In this study, we focused on microvascular microRNAs changes following SA-AKI to identify microRNAs as novel druggable targets and microvasculature-related early biomarkers of SA-AKI. Using small ...
ORGANISM(S): Mus musculus 
2023-12-31 | GSE225193 | GEO
TranscriptomicsThymosin β4 alleviates sepsis-associated acute kidney injury by suppressing MAPK signaling pathway
Sepsis-associated acute kidney injury (SA-AKI) is a common complication in septic patients and is associated with high mortality and progression to chronic kidney disease (CKD). Previous studies have demonstrated that thymosin β4 (Tβ4) attenuates lipopolysaccharide (LPS)-induced liver injury and isc...
ORGANISM(S): Mus musculus 
2026-07-16 | GSE328666 | GEO
TranscriptomicsTranscriptome Analysis of Kidneys in a Mouse Model of Sepsis-Induced Acute Kidney Injury
This study delves into the pathophysiological underpinnings of sepsis-associated acute kidney injury (SA-AKI), a critical and often fatal complication arising from the systemic inflammatory response and immune dysregulation triggered by sepsis. By employing the cecal ligation and puncture (CLP) meth...
ORGANISM(S): Mus musculus 
2025-02-23 | GSE256430 | GEO
TranscriptomicsSepsis Induces Heterogeneous Transcription of Coagulation- and Inflammation-Associated Genes in Renal Microvasculature
# Background Acute kidney injury (AKI) in sepsis patients increases patient mortality. Endothelial cells are important players in the pathophysiology of sepsis-associated AKI (SA-AKI), yet knowledge regarding their spatiotemporal involvement in coagulation disbalance and leukocyte recruitment is lac...
ORGANISM(S): Mus musculus 
2023-12-31 | GSE225192 | GEO
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