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ProteomicsDecoupling astrocytes in adult mice impairs synaptic plasticity and spatial learning
To study the role of the gap junction coupled astrocytic network, we generated inducible double knockouts to selectively delete Cx30 and Cx43 from astrocytes in adult mice. Mice carrying loxP-flanked Gjb6 (Cx30fl/fl mice) (Boulay et al., 2013) and Gja1 (Cx43fl/fl mice) (Theis et al., 2003) alleles w...
ORGANISM(S): Mus musculus (Mouse) 
2022-03-14 | PXD031136 | Pride
Lc-msms Connexin 43 Astrocytes Connexin 30 Hippocampus Mouse Tmt proteomics 
ProteomicsTMT-based proteomics analysis of optic nerve lysates from oligodendrocyte-specific Kir4.1 knockout mice
To study the role oligodendroglial Kir4.1 in regulating axonal energy metabolism, oligodendrocyte-specific Kir4.1 knockout mice and their littermate controls were used; optic nerve lysates were prepared for subsequent TMT-based proteomics.
ORGANISM(S): Mus musculus (Mouse) 
2024-01-30 | PXD046207 | Pride
Lc-msms Mouse Tmt proteomics Optic nerve Oligodendrocytes Kir4.1 knockout 
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