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TranscriptomicsRestoration of regulatory and effector T cell balance and B cell homeostasis in systemic lupus erythematosus patients through vitamin D supplementation
Systemic lupus erythematosus (SLE) is a T and B cell-dependent autoimmune disease characterized by the appearance of autoantibodies, a global regulatory T cells (Tregs) depletion and an increase in Th17 cells. Recent studies have shown the multifaceted immunomodulatory effects of vitamin D, notably ...
ORGANISM(S): Homo sapiens 
2012-03-29 | E-GEOD-36941 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mature, naive B cells to investigate how the PTPN22 autoimmune susceptibility gene affects the removal of human developing autoreactive B cells.
Protein tyrosine phosphatase nonreceptor type 22 (PTPN22) gene segregates with most autoimmune diseases; its risk allele encodes overactive PTPN22 phosphatases that alter B cell receptor (BCR) signaling potentially involved in the regulation of central B cell tolerance. To assess whether PTPN22 ris...
ORGANISM(S): Homo sapiens 
2010-10-16 | E-GEOD-24736 | biostudies-arrayexpress
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