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TranscriptomicsRapid gene expression changes in peripheral blood lymphocytes upon practice of a comprehensive yoga program
One of the most common integrative medicine (IM) modalities is yoga and related practices. Previous work has shown that yoga may improve wellness in healthy people and have benefits for patients. However, the mechanisms of how yoga may positively affect the mind-body system are largely unknown. Here...
ORGANISM(S): Homo sapiens 
2013-04-22 | E-GEOD-44777 | biostudies-arrayexpress
ProteomicsTargeting IRE1α reprograms the tumor microenvironment and enhances anti-tumor immunity in prostate cancer
Unfolded protein response (UPR) is a central stress response pathway in normal cells that is hijacked by tumor cells for their survival. However, how activation of UPR in cancer cells shapes the tumor microenvironment (TME) remain largely unexplored. Here, we investigated the role of IRE1α-XBP1s on...
ORGANISM(S): Mus musculus (Mouse) 
2024-08-28 | PXD044287 | Pride
Ire1 prostate cancer tumor microenvironment 
ProteomicsGlobal proteome analysis of ATF4 targets during ER stress.
Cancer cells exploit many of the cellular adaptive responses to support their survival needs. One such critical pathway in eukaryotic cells is the unfolded protein response (UPR) that is important in normal physiology as well as disease states, including cancer. Since UPR can serve as a lever betwe...
ORGANISM(S): Homo sapiens (Human) 
2019-07-22 | PXD012858 | Pride
Human Lncap cells Lc-ms 
TranscriptomicsTCTP is an androgen-regulated gene implicated in prostate cancer
TCTP has been implicated in a plethora of important cellular processes related to cell growth, cell cycle progression, malignant transformation and inhibition of apoptosis. In addition to these intracellular functions, TCTP has extracellular functions and plays an important role in immune cells. TCT...
ORGANISM(S): Homo sapiens 
2013-10-23 | E-GEOD-47471 | biostudies-arrayexpress
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