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ProteomicsChemogenomic screening in a patient-derived 3D model of metabolic dysfunction-associated steatohepatitis reveals the CHRM1-TRPM8 axis as a novel module for targeted intervention
Metabolic dysfunction-associated steatohepatitis (MASH) is a leading cause of liver disease. A multitude of compounds have been developed in recent years but, due to lack of efficacy or safety concerns, receiving market approval has been challenging and restricted. These failures emphasize the need...
ORGANISM(S): Homo sapiens (Human) 
2024-11-28 | PXD052956 | Pride
Nash  muscarinic receptor  phenotypic assay  target discovery  chemical probes  fibrosis. 
UnknownEzrin, radixin, and moesin are dispensable for macrophage migration and cellular cortex mechanics.
Not available
S-EPMC11535515 | biostudies-literature
ProteomicsPolymorphisms of the vitamin D receptor regulate T cells and T cell dependent inflammatory diseases
Complex autoimmune diseases have proven difficult to dissect down to their causative genetic mechanisms. As a result, epidemiological data from different human association studies are often merged to arrive at a working hypothesis. In one of such examples, lack of sun exposure and consequent lower s...
ORGANISM(S): Mus musculus (Mouse) 
2020-09-28 | PXD019876 | Pride
T cell Inflammatory disease Vitamin d3 
UnknownRisk scores identifying elderly inpatients at risk of 30-day unplanned readmission and accident and emergency department visit: a systematic review.
Not available
S-EPMC6677948 | biostudies-literature
UnknownEncorafenib plus binimetinib versus dabrafenib plus trametinib for the first-line treatment of patients with BRAF<sup>V600E</sup>-mutant metastatic non-small cell lung cancer: a matching-adjusted indirect treatment comparison.
Not available
S-EPMC12865620 | biostudies-literature
UnknownLow-Diversity Microbiota in Apical Periodontitis and High Blood Pressure Are Signatures of the Severity of Apical Lesions in Humans.
Not available
S-EPMC9866854 | biostudies-literature
UnknownMitochondrial reshaping accompanies neural differentiation in the developing spinal cord.
Not available
S-EPMC4447341 | biostudies-literature
UnknownMeteorological factors and rhegmatogenous retinal detachment in metropolitan France.
Not available
S-EPMC11324743 | biostudies-literature
UnknownPrevalence and consequences of psoriasis in recent axial spondyloarthritis: an analysis of the DESIR cohort over 6 years.
Not available
S-EPMC8804683 | biostudies-literature
UnknownBaseline SUVmax is related to tumor cell proliferation and patient outcome in follicular lymphoma.
Not available
S-EPMC8719066 | biostudies-literature
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