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GenomicCIDR: Collaborative Study on the Genetics of Alcoholism (COGA)

This is a case-control study of alcoholism, in which the subjects have been drawn from the Collaborative Study on the Genetics of Alcoholism (COGA), a large, ongoing family-based study that includes subjects from seven sites around the US. COGA has gathered detailed, standardized data on ...

phs000125 | dbGaP
no omics definedTranscription profiling of mouse skeletal muscle in streptozotocin diabetes with or without insulin treatment
Metabolic abnormalities underlying diabetes are primarily the result of the lack of adequate insulin action and the associated changes in protein phosphorylation and gene expression. Affymetrix oligonucleotide microarrays were used to study the changes in the transcriptional program of mouse skeleta...
ORGANISM(S): Mus musculus 
2007-04-05 | E-CBIL-25 | biostudies-arrayexpress
TranscriptomicsHuman skeletal muscle - type 2 diabetes and family history positive individuals - Mexican American
Type 2 diabetes mellitus (DM) is characterized by insulin resistance and pancreatic beta-cell dysfunction. In high-risk subjects, the earliest detectable abnormality is insulin resistance in skeletal muscle. Impaired insulin-mediated signaling, gene expression, and glycogen synthesis, and accumulati...
ORGANISM(S): Homo sapiens 
2010-04-27 | E-GEOD-21340 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of muscle insulin receptor knock-out mice treated with streptozotocin to induce diabetes
The targeted muscle insulin receptor knockout (MIRKO) model was used, in which there is a complete absence of the insulin-receptor signaling in skeletal muscle but normal insulin and glucose levels. By comparing skeletal muscle gene-expression profiles from MIRKO mice and their controls (lox/lox) u...
ORGANISM(S): Mus musculus 
2006-11-24 | E-CBIL-19 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of skeletal muscle from diabetic or non-diabetic Mexican Americans with or without a family history of diabetes
Type 2 diabetes mellitus (DM) is characterized by insulin resistance and pancreatic beta-cell dysfunction. In high-risk subjects, the earliest detectable abnormality is insulin resistance in skeletal muscle. Impaired insulin-mediated signaling, gene expression, and glycogen synthesis, and accumulati...
ORGANISM(S): Homo sapiens 
2007-06-28 | E-CBIL-28 | biostudies-arrayexpress
UnknownDiagnostic Criteria for Identifying Individuals at High Risk of Progression From Mild or Moderate to Severe Alcohol Use Disorder.
Not available
S-EPMC10565602 | biostudies-literature
UnknownParsing genetically influenced risk pathways: genetic loci impact problematic alcohol use via externalizing and specific risk.
Not available
S-EPMC9525649 | biostudies-literature
UnknownGenetic diversity fuels gene discovery for tobacco and alcohol use.
Not available
S-EPMC9771818 | biostudies-literature
UnknownSame data, different analysts: variation in effect sizes due to analytical decisions in ecology and evolutionary biology.
Not available
S-EPMC11804095 | biostudies-literature
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