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TranscriptomicsHuman umbilical cord blood-derived endothelial colony forming cells under serum-free conditions
Derivation and expansion of human umbilical cord blood-derived endothelial colony forming cells under serum-free conditions - a transcriptome analysis. Endothelial colony forming cells (ECFCs) were isolated from term umbilical cord blood units. ECFCs were expanded under standard, fetal bovine serum ...
ORGANISM(S): Homo sapiens 
2010-07-29 | E-GEOD-20504 | biostudies-arrayexpress
TranscriptomicsGene Expression in mice liver after knockdown of Rab5
RNAi-mediated silencing of Rab5 and the consequent loss of endosomes in the mouse liver caused severe metabolic defects such as hypoglycemia, hepatomegaly, hypercholesterolemia, hyperlipidemia and glycogen accumulation. Gene expression in mice liver after knockdown of Rab5 has been performed the Mou...
ORGANISM(S): Mus musculus 
2015-05-03 | E-GEOD-67227 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse ES cell derived brachyury+ (T) cell specific transcriptome
This experiment is part of the FunGenES project (FunGenES - Functional Genomics in Embryonic Stem Cells partially funded by the 6th Framework Programme of the European Union, http://www.fungenes.org). The experiment was conducted at University of Cologne, Cologne, Germany. Goal of the experiment was...
ORGANISM(S): Mus musculus 
2010-05-12 | E-TABM-716 | biostudies-arrayexpress
TranscriptomicsNeuronal-specific Deficiency of the Splicing Factor Tra2b Causes p21-mediated Apoptosis in Neurogenic Areas of the Developing Mouse Brain
Alternative splicing (AS) increases the informational content of the genome and is more prevalent in the brain than in any other tissue. The splicing factor Tra2b (Sfrs10) can modulate splicing inclusion of exons by specifically detecting GAA-rich binding motifs and its absence causes early embryoni...
ORGANISM(S): Mus musculus 
2013-12-16 | E-MTAB-2157 | biostudies-arrayexpress
TranscriptomicsExpression data from differentiating murine embryonic stem cells
Various substances have been reported to enhance the cardiac differentiation of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). Ascorbic Acid had a cardiogenic effect in mESC CGR8 cell line. Transcriptome of AA-treated CGR8 ESCs did not reveal any significant changes in gene ...
ORGANISM(S): Mus musculus 
2015-05-21 | E-GEOD-54242 | biostudies-arrayexpress
TranscriptomicsFungenES: FunGenES_UKOE-4: Functional characterization and transcriptome analysis of embryonic stem cells-derived contractile smooth muscle cells
This experiment is part of the FunGenES project (FunGenES - Functional Genomics in Embryonic Stem Cells partially funded by the 6th Framework Programme of the EuropeanUnion, http://www.fungenes.org). The experiment was conducted at University of Cologne, Cologne, Germany. Goal of the experiment is a...
ORGANISM(S): Mus musculus 
2011-02-25 | E-TABM-1123 | biostudies-arrayexpress
TranscriptomicsMicroarray mRNA data of RPTEC/TERT1 cells exposed to nephrotoxic chemicals ochratoxin A and potassium bromate
Human renal proximal tubule cells (RPTEC/TERT1) were exposed to one of two nephrotoxic chemicals, ochratoxin A (OA) or potassium bromate (KB), or a vehicle control (CT). The exposure regime was a repeated dosing every 24h for 5 days followed by chemical washout and 3 days of recovery with medium ren...
ORGANISM(S): Homo sapiens 
2018-09-16 | E-MTAB-7048 | biostudies-arrayexpress
TranscriptomicsIn vitro assessment of drug-induced liver steatosis based on human dermal stem cell-derived hepatic cells.
Human skin-derived precursor cells (hSKP) are a post natal stem cell population isolated from the dermis. These cells acquire hepatic characteristics upon differentiation with hepatogenic factors. Differentiated hSKP show characteristics of hepatocyte precursor cells and respond to hepatotoxic compo...
ORGANISM(S): Homo sapiens 
2015-01-30 | E-GEOD-62547 | biostudies-arrayexpress
TranscriptomicsMolecular anatomy of gene expression responses in stressed hepatocytes
It is well-known that isolation and cultivation of primary hepatocytes causes major gene expression alterations. In the present genome-wide, time resolved study of cultivated human and mouse hepatocytes, we made the observation that expression changes in culture strongly resemble alterations in live...
ORGANISM(S): Mus musculus 
2016-09-28 | E-MTAB-4444 | biostudies-arrayexpress
TranscriptomicsPro-inflammatory stimulation of human skin-derived precursor cells modulates several of their immunology-related pathways.
Human skin-derived precursor cells (hSKP) are a stem cell population that represents key candidates for cell based-therapy. Inflammation, however, is often present in situations where cellular replacement therapy is required. These inflammatory conditions, and more specifically the presence of the c...
ORGANISM(S): Homo sapiens 
2014-03-03 | E-GEOD-48757 | biostudies-arrayexpress
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