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TranscriptomicsA cross species and multi-omics (including metabolomics) analysis in pancreatic neuroendocrine tumours (tumor stages)
Pancreatic neuroendocrine tumor (PanNET) is relatively infrequent but is nevertheless metastatic. Seeking to extend a new paradigm of personalized medicine, we performed an integrative analysis of transcriptomic (mRNA and microRNA) and mutational profiles and defined three clinically relevant human ...
ORGANISM(S): Mus musculus 
2015-10-30 | E-GEOD-73514 | biostudies-arrayexpress
TranscriptomicsPancreatic endocrine tumours: expression profiling evidences a rold for AKT-mTOR pathway
We investigated the global gene expression in a large panel of pancreatic endocrine tumours (PETs) aimed at identifying new potential targets for therapy and biomarkers to predict patient outcome. Total RNA was extracted from frozen tissue and hybridized on a custom 18.5K human oligo microarrays obt...
ORGANISM(S): Homo sapiens 
2015-10-30 | E-GEOD-73338 | biostudies-arrayexpress
TranscriptomicsA cross species and multi-omics (including metabolomics) analysis in pancreatic neuroendocrine tumours
Pancreatic neuroendocrine tumor (PanNET) is relatively infrequent but is nevertheless metastatic. Seeking to extend a new paradigm of personalized medicine, we performed an integrative analysis of transcriptomic (mRNA and microRNA) and mutational profiles and defined three clinically relevant human ...
ORGANISM(S): Homo sapiens 
2015-10-30 | E-GEOD-73339 | biostudies-arrayexpress
TranscriptomicsA cross species and multi-omics (including metabolomics) analysis in pancreatic neuroendocrine tumours (miRNA)
Pancreatic neuroendocrine tumor (PanNET) is relatively infrequent but is nevertheless metastatic. Seeking to extend a new paradigm of personalized medicine, we performed an integrative analysis of transcriptomic (mRNA and microRNA) and mutational profiles and defined three clinically relevant human ...
ORGANISM(S): Homo sapiens 
2015-10-30 | E-GEOD-73367 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression abnormalities in pancreatic endocrine and acinar tumours are associated with distinctive pathologic features and clinical behavior
We investigated the global microRNA expression patterns in normal pancreas, pancreatic endocrine tumours and acinar carcinomas to evaluate their involvement in transformation and malignant progression of these tumour types. A neoplastic cellularity higher than 90% was obtained by cryostat enrichment...
ORGANISM(S): Homo sapiens 
2015-10-30 | E-GEOD-73350 | biostudies-arrayexpress
TranscriptomicsExon profiling of human Gray (LBNL) breast cancer cell lines
Exon array profiling of Gray (LBNL) breast cancer cell lines
ORGANISM(S): Homo sapiens 
2010-12-01 | E-MTAB-181 | biostudies-arrayexpress
TranscriptomicsGene expression signature in advanced colorectal cancer patients select drugs and response for the use of leucovorin, fluorouracil, and irinotecan
In patients with advanced colorectal cancer, leucovorin, fluorouracil, and irinotecan (FOLFIRI) is considered as one of the reference first-line treatments. However, only about half of treated patients respond to this regimen, and there is no clinically useful marker that predicts response. A major ...
ORGANISM(S): Homo sapiens 
2014-10-06 | E-GEOD-62080 | biostudies-arrayexpress
TranscriptomicsPervasive subtypes of pancreatic ductal adenocarcinoma (PDA) and their differing response to therapy.
Pancreatic ductal adenocarcinoma (PDA) carries a dismal prognosis and current treatments are only modestly effective. We present evidence that this variation is caused in part by recurrent, pervasive molecular differences between tumors. mRNA expression profiles measured using microdissected PDA cli...
ORGANISM(S): Mus musculus 
2011-04-01 | E-GEOD-17891 | biostudies-arrayexpress
ProteomicsComprehensive proteomic profiling of the differences between Cancer Associated Fibroblasts and KRAS mutated cancer cell lines
Cancer associated fibroblasts (CAFs) are a key component of tumors. We aimed to profile the proteome of cancer cell lines representing three common cancer types (lung, colorectal and pancreatic) and a representative CAF cell line from each tumor type to gain insight into CAF function and identify ne...
ORGANISM(S): Homo sapiens (Human) 
2024-08-22 | PXD054500 | Pride
Cancer associated fibroblasts Kras Cafs 
GenomicsAssessment of genomic copy number alterations in breast cancer
The aim of this study was to assess genomic copy number alterations in a panel of breast cancer cell lines. These data were used to identify common aberrations associated with breast cancer, and also to identify aberrations associated with response to therapeutic compounds.
EGAS00000000059 | EGA
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