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ProteomicsSARS-CoV-2 nsp15 enhances viral virulence by subverting host antiviral defenses
SARS-CoV-2 encodes numerous virulence factors, yet their precise mechanisms of action remain unknown. We provide evidence that the SARS-CoV-2 non-structural protein 15 (nsp15) enhances viral virulence by suppressing the production of viral double-stranded (dsRNA), a potent inducer of antiviral signa...
ORGANISM(S): Homo sapiens (Human) 
2025-06-30 | PXD056702 | Pride
Nsp15 Sars-cov-2 
ProteomicsMulti-cell type proteomic profiling reveals desensitization of SARS-CoV-2-infected cells to interferon treatment
SARS-CoV-2, the coronavirus behind the ongoing pandemic, manifests itself in a broad array of symptoms involving various body organs, such as lungs, intestine, kidneys, heart, liver, and brain. To investigate how SARS-CoV-2 navigates disparate organs and alters their biology, we engineered a panel o...
ORGANISM(S): Homo sapiens (Human) 
2021-07-27 | PXD022027 | Pride
Immune evasion Sars-cov-2 Proteomics Interferon signaling Receptor tyrosine kinases Virus-host interactions Stat phosphorylation Human cell lines 
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