Nsp15 - OmicsDI

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SARS-CoV-2 nsp15 enhances viral virulence by subverting host antiviral defenses

SARS-CoV-2 encodes numerous virulence factors, yet their precise mechanisms of action remain unknown. We provide evidence that the SARS-CoV-2 non-structural protein 15 (nsp15) enhances viral virulence by suppressing the production of viral double-stranded (dsRNA), a potent inducer of antiviral signa...

ORGANISM(S): Homo sapiens (Human)

2025-06-30 | PXD056702 | Pride

Nsp15 Sars-cov-2

Host transcriptome in human lung A549 cells infected with SARS-CoV-2 expressing wild-type and mutant (H234A and N277A) Nsp15

Coronavirus (CoV) Nsp15 is a viral endoribonuclease (EndoU) with a preference for uridine residues. CoV Nsp15 is an innate immune antagonist which prevents dsRNA sensor recognition and stress granule formation by targeting viral and host RNAs. SARS-CoV-2 restricts and delays the host antiviral innat...

ORGANISM(S): Homo sapiens

2025-12-31 | GSE274310 | GEO

Cleavage sequence specificity of Nsp15.

Not available

S-EPMC12128668 | biostudies-literature

Regulation of coronavirus nsp15 cleavage specificity by RNA structure.

Not available

S-EPMC10449227 | biostudies-literature

Cryo-EM Structures of the SARS-CoV-2 Endoribonuclease Nsp15.

Not available

S-EPMC7427136 | biostudies-literature

Characterization of SARS2 Nsp15 nuclease activity reveals it's mad about U.