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ProteomicsThe dissociation of RQT complex on ribosome
Ribosome-associated quality control (RQC) represents a rescue pathway in eukaryotic cells triggered upon translational stalling. Collided ribosomes are recognized for subsequent dissociation followed by targeting of the faulty nascent peptides for degradation. However, endogenous RQC inducing sequen...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2020-02-24 | PXD017196 | Pride
Yeast In vitro reaction Ribosome 
ProteomicsDNMT1 IP-MS alalysis to identify ubiquitin-dependent interacting partners
Stable inheritance of DNA methylation is critical for maintaining the differentiated phenotypes in multicellular organisms. However, the molecular basis ensuring high fidelity of maintenance DNA methylation is largely unknown. Here, we demonstrate that two distinct modes of DNMT1 recruitment, one is...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2020-02-25 | PXD015282 | Pride
Dnmt1 ubiquitin 
ProteomicsTMTpro 16-plex analysis of siRAD23B and siControl in replicatively and ETP-treated senescent cells
Replicatively-senescent and ETP-treated senescent WI-38 cells were transfected with siRNAs (Stealth Select RNAi RAD23B siRNA #1 and siGENOME non-targeting control siRNA #2) using Lipofectamine RNAiMAX in four biological replicates. At 72 h after transfection, the cells were washed twice with cold-PB...
ORGANISM(S): Homo Sapiens (human) 
2023-07-22 | PXD028626 | JPOST Repository
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