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ProteomicsBS3 intermolecular crosslinking map of SAGA and SLIK (SAGA-like) transcription coactivators
The SAGA-like complex SLIK is a modified version of the Spt-Ada-Gcn5-Acetyltransferase (SAGA) complex. SLIK is formed through C-terminal truncation of the Spt7 SAGA subunit, causing loss of Spt8 that interacts with the TATA-binding protein. SLIK and SAGA are both coactivators of RNA polymerase II tr...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-04-19 | PXD024640 | Pride
Dna-protein interaction Cryo-electron microscopy Histone deubiquitination Transcriptional coactivator Histone acetylation 
TranscriptomicsTranscription profiling of S. cerevisiae wild type reference strain, two simple mutants (not1-2 and spt3) and one double mutant (not1-2 spt3) reveals a SAGA-Independent function of SPT3 mediates transcriptional deregulation in a mutant of the Ccr4-Not Complex
The conserved multi-subunit Ccr4-Not complex regulates gene expression in diverse ways. In this work, we characterize the suppression of temperature sensitivity associated with a mutation in the gene encoding the scaffold subunit of the Ccr4-Not complex, NOT1, by the deletion of SPT3. We determine t...
ORGANISM(S): Saccharomyces cerevisiae 
2008-06-16 | E-GEOD-9432 | biostudies-arrayexpress
ProteomicsTwo related coactivator complexes SAGA and ATAC control embryonic stem cell self-renewal through two different acetyltransferase-independent mechanisms
SAGA and ATAC are two related transcriptional coactivator complexes, sharing the same histone acetyltransferase (HAT) subunit. The HAT activities of SAGA and ATAC are required for metazoan development but the precise role of the two complexes in RNA polymerase II transcription in mammals is less und...
ORGANISM(S): Mus musculus (Mouse) 
2021-08-11 | PXD027026 | Pride
Saga Newly synthesized rna Histone acetyltransferase 4su labelling Atac Pol ii transcription Hat-independent function Mouse embryonic stem cells Coactivator complexes 
GenomicsPost-transcription initiation function of the ubiquitous SAGA complex in tissue-specific gene activation (ChIP-seq)
SAGA is a highly conserved transcriptional co-activator complex involved in multiple steps of transcription with activities that function both pre and post initiation. Loss of individual subunits results in developmental defects, suggesting a role in development. To better understand the roles of SA...
ORGANISM(S): Drosophila melanogaster 
2011-08-22 | E-GEOD-29513 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of fission yeast SAGA mutants shows that the SAGA complex controls the switch from proliferation to sexual differentiation through the opposing roles of its subunits Gcn5 and Spt8
The SAGA complex is a conserved multifunctional coactivator known to play broad roles in eukaryotic transcription. To gain new insights into its functions, we have performed biochemical and genetic analyses of SAGA in the fission yeast, Schizosaccharomyces pombe. Purification of the S. pombe SAGA ...
ORGANISM(S): Schizosaccharomyces pombe 
2008-11-19 | E-MTAB-53 | biostudies-arrayexpress
TranscriptomicsTra1 has specific regulatory roles, rather than global functions, within the SAGA coactivator complex
The SAGA complex is a conserved, multifunctional coactivator that plays broad roles in eukaryotic transcription. Previous studies suggested that Tra1, the largest SAGA component, is required either for SAGA assembly or for recruitment by DNA-bound transcriptional activators. In contrast to S. cere...
ORGANISM(S): Schizosaccharomyces pombe 
2011-06-13 | E-MTAB-678 | biostudies-arrayexpress
GenomicsConserved and unique features of the SAGA complex in plants [RNA-seq]
Conserved and unique features of the SAGA complex in plants [RNA-seq]
PRJNA678688 | ENA
GenomicsConserved and unique features of the SAGA complex in plants [ChIP-seq]
Conserved and unique features of the SAGA complex in plants [ChIP-seq]
PRJNA678687 | ENA
GenomicsMyc and SAGA Rewire an Alternative Splicing Network During Early Somatic Cell Reprogramming [Reprogramming_ChIPSEQ]
Embryonic stem cells are maintained in a self-renewing and pluripotent state by multiple regulatory pathways. Pluripotent-specific transcriptional networks are sequentially reactivated as somatic cells reprogram to achieve pluripotency. How epigenetic regulators modulate this process and contribute ...
ORGANISM(S): Mus musculus 
2015-04-15 | E-GEOD-67694 | biostudies-arrayexpress
TranscriptomicsMyc and SAGA Rewire an Alternative Splicing Network During Early Somatic Cell Reprogramming [Reprogramming_RNASEQ]
Embryonic stem cells are maintained in a self-renewing and pluripotent state by multiple regulatory pathways. Pluripotent-specific transcriptional networks are sequentially reactivated as somatic cells reprogram to achieve pluripotency. How epigenetic regulators modulate this process and contribute ...
ORGANISM(S): Mus musculus 
2015-04-15 | E-GEOD-67715 | biostudies-arrayexpress
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