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ProteomicsBS3 intermolecular crosslinking map of SAGA and SLIK (SAGA-like) transcription coactivators
The SAGA-like complex SLIK is a modified version of the Spt-Ada-Gcn5-Acetyltransferase (SAGA) complex. SLIK is formed through C-terminal truncation of the Spt7 SAGA subunit, causing loss of Spt8 that interacts with the TATA-binding protein. SLIK and SAGA are both coactivators of RNA polymerase II tr...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-04-19 | PXD024640 | Pride
Dna-protein interaction Cryo-electron microscopy Histone deubiquitination Transcriptional coactivator Histone acetylation 
TranscriptomicsGenome-wide regulation by TFIID and SAGA
TFIID and SAGA share a common set of TAFs, regulate chromatin, and deliver TBP to promoters. Here we examine their relationship within the context of the Saccharomyces cerevisiae genome-wide regulatory network. We find that while TFIID and SAGA make overlapping contributions to the expression of al...
ORGANISM(S): Saccharomyces cerevisiae 
2004-02-26 | E-GEOD-885 | biostudies-arrayexpress
TranscriptomicsTra1 has specific regulatory roles, rather than global functions, within the SAGA coactivator complex
The SAGA complex is a conserved, multifunctional coactivator that plays broad roles in eukaryotic transcription. Previous studies suggested that Tra1, the largest SAGA component, is required either for SAGA assembly or for recruitment by DNA-bound transcriptional activators. In contrast to S. cere...
ORGANISM(S): Schizosaccharomyces pombe 
2011-06-13 | E-MTAB-678 | biostudies-arrayexpress
ProteomicsTwo related coactivator complexes SAGA and ATAC control embryonic stem cell self-renewal through two different acetyltransferase-independent mechanisms
SAGA and ATAC are two related transcriptional coactivator complexes, sharing the same histone acetyltransferase (HAT) subunit. The HAT activities of SAGA and ATAC are required for metazoan development but the precise role of the two complexes in RNA polymerase II transcription in mammals is less und...
ORGANISM(S): Mus musculus (Mouse) 
2021-08-11 | PXD027026 | Pride
Saga Newly synthesized rna Histone acetyltransferase 4su labelling Atac Pol ii transcription Hat-independent function Mouse embryonic stem cells Coactivator complexes 
GenomicsThe SAGA coactivator complex acts on the whole transcribed genome and is required for RNA polymerase II transcription [Yeast cells]
The SAGA co-activator complex contains distinct chromatin-modifying activities and is recruited by DNA-bound activators to regulate the expression of a subset of genes. Surprisingly, recent studies revealed little overlap between genome-wide SAGA-binding profiles and changes in gene expression upon ...
ORGANISM(S): Saccharomyces cerevisiae 
2014-08-29 | E-GEOD-52997 | biostudies-arrayexpress
GenomicsThe SAGA coactivator complex acts on the whole transcribed genome and is required for RNA polymerase II transcription [HeLa cells]
The SAGA co-activator complex contains distinct chromatin-modifying activities and is recruited by DNA-bound activators to regulate the expression of a subset of genes. Surprisingly, recent studies revealed little overlap between genome-wide SAGA-binding profiles and changes in gene expression upon ...
ORGANISM(S): Homo sapiens 
2014-08-29 | E-GEOD-52860 | biostudies-arrayexpress
TranscriptomicsGene deletion expression profiles of SAGA, TREX2 and Sem1
Non-essential knockouts of SAGA, TREX2 and Sem1 have been investigated by expression profiling.
ORGANISM(S): Saccharomyces cerevisiae 
2013-06-04 | E-MTAB-1240 | biostudies-arrayexpress
GenomicsPost-transcription initiation function of the ubiquitous SAGA complex in tissue-specific gene activation (ChIP-seq)
SAGA is a highly conserved transcriptional co-activator complex involved in multiple steps of transcription with activities that function both pre and post initiation. Loss of individual subunits results in developmental defects, suggesting a role in development. To better understand the roles of SA...
ORGANISM(S): Drosophila melanogaster 
2011-08-22 | E-GEOD-29513 | biostudies-arrayexpress
ProteomicsSUPT3H-less SAGA coactivator can assemble and function without significantly perturbing RNA polymerase II transcription in mammalian cells
Co-activator complexes regulate chromatin accessibility and transcription. SAGA (Spt-Ada-Gcn5 Acetyltransferase) is an evolutionary conserved multisubunit co-activator complex with modular organization. The core module of SAGA constitutes the structural heart, composed of a histone octamer like stru...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-07-26 | PXD026991 | Pride
Elisabeth scheer Didier devys Damien plassard Elisabeth lata bastian morlet And lászló tora Veronique fischer Stéphane d. vincent 
UnknownMolecular phylogenetic analysis of bovine papular stomatitis viruses detected in Saga, Japan.
Not available
S-EPMC8498829 | biostudies-literature
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