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ProteomicsHigh-throughput proteomics of the 26 medically most important elapids and vipers from sub-Saharan Africa
Venomous snakes are important parts of the ecosystem, and their behavior and evolution have been shaped by their surrounding environments over the eons. This is reflected in their venoms, which are typically highly adapted for their biological niche, including their diet and defense mechanisms for d...
ORGANISM(S): Bitis gabonica Naja nivea Naja annulifera Naja anchietae Naja katiensis Dendroaspis polylepis Echis pyramidum Bitis arietans Naja nigricincta Cerastes cerastes Dendroaspis angusticeps (Eastern green mamba) (Naja angusticeps) Bitis rhinoceros Naja pallida Naja ashei Echis leucogaster Echis ocellatus Dendroaspis viridis Naja senegalensis Bitis nasicornis Dendroaspis jamesoni Naja nubiae Hemachatus haemachatus Naja mossambica Naja haje Naja nigricollis Naja melanoleuca 
2022-10-17 | PXD036161 | Pride
Snakebite envenoming Snake venom Venomics 
TranscriptomicsThe Lung Microbiome of HIV-infected Pneumonia Patients in Sub-Saharan Africa
Sub-Saharan Africa represents 69% of the total number of individuals living with HIV infection worldwide and 72% of AIDS deaths globally. Pulmonary infection is a common and frequently fatal complication, though little is known regarding the lower airway microbiome composition of this population. Ou...
ORGANISM(S): Homo sapiens 
2014-02-20 | E-GEOD-52791 | biostudies-arrayexpress
UnknownChemo-profiling of Purpureocillium lilacinum and Paecilomyces variotii isolates using GC-MS analysis, and evaluation of their metabolites against M. incognita.
Not available
S-EPMC10868743 | biostudies-literature
MetabolomicsNovel Minor Groove Binders cure animal African trypanosomiasis in an in vivo mouse model
Animal African trypanosomiasis (AAT) is a significant socioeconomic burden for sub-Saharan Africa because of its huge impact on livestock health. Existing therapies including those based on minor groove binders (MGBs), such as the diamidines, which have been used for decades, have now lost efficacy ...
2022-01-18 | MTBLS882 | MetaboLights
MetabolomicsRepurposing the orphan drug nitisinone to control the transmission of African trypanosomiasis
Tsetse transmit African trypanosomiasis, which is a disease fatal to both humans and animals. A vaccine to protect against this disease does not exist so transmission control relies on eliminating tsetse populations. Although neurotoxic insecticides are the gold standard for insect control, they neg...
2021-10-06 | MTBLS2166 | MetaboLights
MetabolomicsIntegrated Exposomics/Metabolomics for Rapid Exposure and Effect Analyses

The totality of environmental exposures and lifestyle factors, commonly referred to as the exposome, are poorly understood. Measuring the myriad of chemicals that humans are exposed to is immensely challenging and identifying disrupted metabolic pathways is even more complex. Here, we present a n...

2023-10-26 | MTBLS4556 | MetaboLights
MetabolomicsUrban living in healthy Tanzanians is associated with an inflammatory status driven by dietary and metabolic changes
Sub-Saharan Africa currently experiences an unprecedented wave of urbanization, which has important consequences for health and disease patterns. This study aimed to investigate and integrate the immune and metabolic consequences of rural or urban lifestyles and the role of nutritional changes assoc...
2021-06-22 | MTBLS2267 | MetaboLights
GenomicsAPCDR AGV Project: WGS of South African Zulu
The African Genome Variation Project (AGVP) provides a resource to help design, implement and interpret genomic studies in sub-Saharan Africa (SSA) and worldwide. The AGVP represents dense genotypes from 1,481 and whole genome sequences (WGS) from 320 individuals across SSA. As part of the AGVP we ...
EGAS00001000286 | EGA
GenomicsAPCDR AGV Project: WGS of an Ugandan population
The African Genome Variation Project (AGVP) provides a resource to help design, implement and interpret genomic studies in sub-Saharan Africa (SSA) and worldwide. The AGVP represents dense genotypes from 1,481 and whole genome sequences (WGS) from 320 individuals across SSA. As part of the AGVP we ...
EGAS00001000363 | EGA
ProteomicsBiomarkers of post-stabilization mortality in severe acute malnutrition
A high rate of early post-discharge mortality has been observed in children admitted with Severe Acute Malnutrition (SAM) in sub-Saharan Africa but the underlying causes and mechanisms are not well understood. We investigated whether there are biomarkers measured before discharge following medical s...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-08-02 | MSV000082745 | MassIVE
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