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GenomicsFoxA1 specifies unique androgen and glucocorticoid receptor binding events in prostate cancer cells (HTS)
We report the androgen receptor recruitment to the chromatin of androgen responsive prostate cancer cell lines, LNCaP-1F5 and VCaP in response to physiological androgen 5a-dihydrotestosterone (DHT) using ChIP-sequencing. We compare the AR recruitment by DHT to that by partial agonist/antagonist cypr...
ORGANISM(S): Homo sapiens 
2013-02-05 | E-GEOD-39879 | biostudies-arrayexpress
GenomicsTissue-specific pioneer factors associate with androgen receptor cistromes and transcription programs. [ChIP-Seq]
We report the in vivo androgen receptor (AR) binding sites in murine prostate, epididymis and kidney in response to physiological androgen testosterone using ChIP-sequencing and gene expression profiling by microarray. From AR cistrome analysis, we identified tissue-specific collaborating factors i....
ORGANISM(S): Mus musculus 
2014-01-21 | E-GEOD-47192 | biostudies-arrayexpress
GenomicsAndrogen receptor uses relaxed response element stringency for selective chromatin binding and transcriptional regulation in vivo
We report the in vivo androgen receptor (AR) binding sites in caput epididymis of intact SPARKI and wild-type mice using ChIP-sequencing. SPARKI (specificity affecting androgen receptor knock-in) mouse line has the second zinc finger of AR replaced by that of glucocorticoid receptors. In vivo analys...
ORGANISM(S): Mus musculus 
2014-01-21 | E-GEOD-51106 | biostudies-arrayexpress
TranscriptomicsFoxA1 specifies unique androgen and glucocorticoid receptor binding events in prostate cancer cells (mRNA)
We report the androgen receptor recruitment to the chromatin of androgen responsive prostate cancer cell lines, LNCaP-1F5 and VCaP in response to physiological androgen 5a-dihydrotestosterone (DHT) using ChIP-sequencing. We compare the AR recruitment by DHT to that by partial agonist/antagonist cypr...
ORGANISM(S): Homo sapiens 
2013-02-05 | E-GEOD-39654 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of PIAS1 on AR gene expression in MDA-MB453
The majority of breast cancer subtypes express androgen receptor (AR) in addition to estrogen receptor α (ERα). Depending on the breast cancer subtype androgen signaling has either stimulatory or inhibitory roles in breast cancer cell growth. We have mapped AR cistrome in ERα negative human molec...
ORGANISM(S): Homo sapiens 
2016-07-18 | E-GEOD-70162 | biostudies-arrayexpress
no omics definedTranscription profiling of human prostate cancer cells over-expressing androgen receptor following dihydrotestosterone treament
dose and time dependent responses of dihydrotestosterone in androgen receptor over-expressing prostate cancer cells.
ORGANISM(S): Homo sapiens 
2009-10-09 | E-MEXP-2286 | biostudies-arrayexpress
GenomicsOverexpression of androgen receptor enhances the binding of the receptor to the chromatin in prostate cancer
Androgen receptor (AR) is overexpressed in the majority of castration-resistant prostate cancers (CRPCs). Our goal was to study the effect of AR overexpression on the chromatin binding of the receptor and to identify AR target genes that may be important in the emergence of CRPC. We have established...
ORGANISM(S): Homo sapiens 
2013-06-27 | E-GEOD-48308 | biostudies-arrayexpress
TranscriptomicsCytoplasmic Accumulation of Incompletely Glycosylated Sex Hormone-binding Globulin (SHBG) Enhances Androgen Action in Proximal Convoluted Tubule Epithelial Cells
Identification of androgen-responsive genes that are influenced by the presence of a functional SHBG versus a steroid-binding-deficient SHBG mutant (SHBG S42L) in the cytoplasm of PCT cells. The hypothesis tested in the study was that SHBG enhances androgen action. Results provide important informat...
ORGANISM(S): Mus musculus 
2010-12-15 | E-GEOD-26058 | biostudies-arrayexpress
TranscriptomicsTissue-specific pioneer factors associate with androgen receptor cistromes and transcription programs. [microarray]
We report the in vivo androgen receptor (AR) binding sites in murine prostate, epididymis and kidney in response to physiological androgen testosterone using ChIP-sequencing and gene expression profiling by microarray. From AR cistrome analysis, we identified tissue-specific collaborating factors i....
ORGANISM(S): Mus musculus 
2014-01-21 | E-GEOD-47181 | biostudies-arrayexpress
GenomicsDual Role of FoxA1 in Androgen Receptor Binding to Chromatin, Androgen Signaling and Prostate Cancer [ChIP_seq, DHS_seq]
We report the dual role of FoxA1 in androgen receptor recruitment to the chromatin of androgen responsive prostate cancer cell line LNCaP-1F5 using ChIP-sequencing. Depletion of FoxA1 reprograms both androgen and glucocorticoid receptor recruitment and subsequent gene expression. The ChIP-seq has be...
ORGANISM(S): Homo sapiens 
2011-09-14 | E-GEOD-30623 | biostudies-arrayexpress
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