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ProteomicsTime-course global proteome analyses in the APPNL-F mouse model of Alzheimer disease
A hallmark of Alzheimer Disease is the accumulation of aggregation-prone amyloid beta peptides, which can assemble into smaller aggregates and deposit in the form of amyloid plaques. Here we used the recently introduced APPNL-F mouse model of Alzheimer Disease, which faithfully recapitulates the amy...
ORGANISM(S): Mus musculus (Mouse) 
2017-08-02 | PXD004439 | Pride
Mouse Brain Amyloid beta Lc-ms/ms 
ProteomicsImpaired presynaptic proteostasis in the initial stages of amyloid beta proteotoxicity
Compromised protein homeostasis underlies accumulation of plaques and tangles in Alzheimers disease (AD); however, little is known about the early mechanisms that contribute to this accumulation. To objectively assess the impaired protein turnover at early stages of amyloid beta (Abeta) proteotoxic...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2020-02-24 | MSV000085004 | MassIVE
ProteomicsProteomic analysis of cochlear perilymph in a mouse model of Alzheimer's disease
This study referred to the changes in protein abundance of App(NL-GF/NL-GF) and App(wt/wt) mice perilymph. Liquid chromatography-tandem mass spectrometry with MS2-based quantification of tandem mass tag was utilized.
ORGANISM(S): Mus Musculus (mouse) 
2024-04-15 | PXD046317 | JPOST Repository
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