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TranscriptomicsComparison of gene expression profiles of anaplastic glioma with or without the mutated IDH1/2 gene
To examine the NRF2 activity in anaplastic glioma with mutated IDH1/2, we conducted the microarray analysis to measure the expression levels of representative NRF2 target genes, including NQO1, HMOX1, GCLM, TXNRD1, and PRDX1. 12 anaplastic gliomas with or without mutated IDH1/2.
ORGANISM(S): Homo sapiens 
2013-12-04 | E-GEOD-52942 | biostudies-arrayexpress
TranscriptomicsHuman cathelicidin antimicrobial peptide LL37 effect on human neonatal epidermal keratinocytes (NHEKs).
Analysis of undifferentiated keratinocytes or differentiated keratinocytes stimulated with or without human cathelicidin antimicrobial peptide (CAMP) LL37. Results provide insight into the biological effects of CAMP on human keratinocytes. NHEKs were divided into two groups; low calcium (0.05 mM) an...
ORGANISM(S): Homo sapiens 
2014-08-01 | E-GEOD-49472 | biostudies-arrayexpress
Transcriptomicshuman Nalm6 Cells: WT vs. OGFOD1 KO
The 2-OG-Fe(II) dioxygenase family are critical for cellular adaptation to changes in oxygen concentration. We found that cells with OGFOD1 gene silencing in this family showed resistance to cell death under ischemia, and cDNA microarray analysis of OGFOD1 knockout human cells revealed downregulatio...
ORGANISM(S): Homo sapiens 
2010-04-29 | E-GEOD-21557 | biostudies-arrayexpress
TranscriptomicsInduced overexpression of Pdx1 and Ngn3 in a mouse ES cell-derived endoderm population induces pancreatic differentiation
Induced overexpression of Pdx1 in activin-induced endoderm population resulted in the upregulation of pancreas-related genes such as insulin 1 and 2 at day 20. To enhance the developmental progression from the pancreatic bud to the formation of the endocrine lineages, we next expressed neurogenin3 ...
ORGANISM(S): Mus musculus 
2010-08-24 | E-GEOD-23752 | biostudies-arrayexpress
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