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no omics definedTranscription profiling of human mesenchymal stem cells transfected with adenoviruses carrying the SOX trio or LacZ control to identify target molecules
The aim of the experiment is to identify target molecules of the SOX trio (SOX9, SOX5 and SOX6). hMSC were transfected with the adenoviruses carrying the SOX trio or the LacZ-control, and total RNA was isolated after 2 weeks of culture.
ORGANISM(S): Homo sapiens 
2007-04-01 | E-MEXP-960 | biostudies-arrayexpress
MetabolomicsNiacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma (Cell NAMPTi treatment)

NAMPT plays a major role in NAD biosynthesis in many cancers and is an attractive potential cancer target. However, factors dictating therapeutic efficacy of NAMPT inhibitors (NAMPTi) are unclear. We report that neuroendocrine phenotypes predict lung and prostate carcinoma vulnerability to NAMPTi...

2023-10-10 | MTBLS7251 | MetaboLights
MetabolomicsNiacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma (Mouse NAD targeted time-course)

NAMPT plays a major role in NAD biosynthesis in many cancers and is an attractive potential cancer target. However, factors dictating therapeutic efficacy of NAMPT inhibitors (NAMPTi) are unclear. We report that neuroendocrine phenotypes predict lung and prostate carcinoma vulnerability to NAMPTi...

2023-10-10 | MTBLS7253 | MetaboLights
MetabolomicsNiacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma (Mouse NAMPT targeted therapy)

NAMPT plays a major role in NAD biosynthesis in many cancers and is an attractive potential cancer target. However, factors dictating therapeutic efficacy of NAMPT inhibitors (NAMPTi) are unclear. We report that neuroendocrine phenotypes predict lung and prostate carcinoma vulnerability to NAMPTi...

2023-10-10 | MTBLS7252 | MetaboLights
TranscriptomicsGene expression alteration in chondrocyte by HES1 overexpression
To investigate target molecules of HES1, we transduced GFP or HES1 into mouse chondrocyte cell line ATDC5, and performed the microarray analysis. HES1 overexpression increased inflammation-related genes including Il6 and Il1rl1. We established stable ATDC5 cells overexpressing GFP or HES1 by lentivi...
ORGANISM(S): Mus musculus 
2015-03-02 | E-GEOD-60737 | biostudies-arrayexpress
UnknownRab5b-Associated Arf1 GTPase Regulates Export of N-Myristoylated Adenylate Kinase 2 From the Endoplasmic Reticulum in Plasmodium falciparum.
Not available
S-EPMC7884776 | biostudies-literature
TranscriptomicsGene expression alteration in chondrocyte by A-CEBP overexpression.
To investigate loss-of-function of the C/EBP family members, we used A-CEBP which exerts a dominant-negative effect against all CEBPs. DOX-inducible overexpression of A-CEBP into mouse chondrocyte cell line ATDC5 increased expressions of early differentiation markers, decreased those of late differe...
ORGANISM(S): Mus musculus 
2014-11-01 | E-GEOD-60651 | biostudies-arrayexpress
GenomicsGenome-wide maps of HES1 binding-site in human chondrogenic cell.
Notch signaling modulates skeletal formation and osteoarthritis (OA) development through induction of catabolic factors. Here we examined functional roles of Hes1, the representative downstream transcription factor of Notch signaling, during these processes. Chromatin immunoprecipitation-sequencing...
ORGANISM(S): Homo sapiens 
2014-08-02 | E-GEOD-60006 | biostudies-arrayexpress
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