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TranscriptomicsA Pathobiological Role of the Insulin Receptor in CLL.
Purpose: The chromosomal deletion 11q affects biology and clinical outcome in CLL but del11q-deregulated genes remain incompletely characterized. Results: We have identified differential expression of the insulin receptor (INSR) in CLL, including high-level INSR expression in the majority of CLL wi...
ORGANISM(S): Homo sapiens 
2011-05-05 | E-GEOD-26526 | biostudies-arrayexpress
TranscriptomicsClonal evolution, genomic drivers, and effects of therapy in chronic lymphocytic leukemia
The identification of gene mutation and structural genomic aberrations that are critically involved in CLL pathogenesis is still evolving. One may postulate that genomic driver lesions with effects on CLL proliferation, apoptosis thresholds, or chemotherapy resistance should increase in frequency o...
ORGANISM(S): Homo sapiens 
2013-04-19 | E-GEOD-45565 | biostudies-arrayexpress
TranscriptomicsIntegrated Genomic Profiling, Therapy Response And Survival In Adult Acute Myelogenous Leukemia
Recurrent gene mutations, chromosomal translocations, acquired genomic copy number aberrations (aCNA) and copy-neutral loss-of-heterozygosity (cnLOH) underlie the genomic pathogenesis of acute myelogenous leukemia (AML). Genomic lesion types from all of these categories have been variously associat...
ORGANISM(S): Homo sapiens 
2015-03-01 | E-GEOD-61323 | biostudies-arrayexpress
TranscriptomicsAnalysis of the coding exome of follicular lymphoma
Follicular lymphoma (FL) constitutes the second most common non-Hodgkin lymphoma in the Western world. FL carries characteristic recurrent structural genomic aberrations. However, information regarding the coding genome in FL is still evolving. Here, we describe the results of massively parallel ex...
ORGANISM(S): Homo sapiens 
2014-01-17 | E-GEOD-50973 | biostudies-arrayexpress
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