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TranscriptomicsT7-SAGE transcriptome of cleft versus end bud epithelial cells of embryonic mouse salivary glands
Mus musculus embryonic submandibular salivary glands from embryonic day 12.5 embryos were laser microdissected to isolate epithelial cells from regions adjacent to forming clefts or from the peripheral end bud region. The isolated region-specific samples were then subjected to T7-SAGE transcriptome ...
ORGANISM(S): Mus musculus 
2010-06-16 | E-GEOD-22374 | biostudies-arrayexpress
TranscriptomicsRegulation of the epithelial adhesion molecule CEACAM1 is essential for palate formation.
Cleft palate results from a mixture of genetic and environmental factors and occurs when the bilateral palatal shelves fail to fuse. The objective of this study was to search for new genes involved in mouse palate formation. Gene expression of murine embryonic palatal tissue was analyzed at the vari...
ORGANISM(S): Mus musculus 
2013-01-23 | E-GEOD-43651 | biostudies-arrayexpress
TranscriptomicsMicroRNA-27a regulates lipid metabolism and inhibits hepatitis C virus replication in human hepatoma cells
Gene expression profiling was carried out in Huh-7.5 cells in which miR-27a was over- or under-expressed. Transfection of cells with pre-miR-27a and pre-miR-control, or anti-miR-27a and anti-miR-control enabled down- and up-regulated genes to be determined, respectively. Replication and infectivity ...
ORGANISM(S): Homo sapiens 
2013-06-05 | E-GEOD-41737 | biostudies-arrayexpress
TranscriptomicsSerial gene expression profiling in the liver of Pdgf-c Tg mice that developed hepatic fibrosis and tumors
Over expression of PDGF-C in mouse liver resulted in the progression of hepatic fibrosis, steatosis and the development of HCC; this mouse model closely resembles the human HCC that is frequently associated with hepatic fibrosis. Peretinoin (generic name; code, NIK-333), developed by the Kowa Compan...
ORGANISM(S): Mus musculus 
2012-10-03 | E-GEOD-31431 | biostudies-arrayexpress
TranscriptomicsAcyclic retinoid targets platelet-derived growth factor signaling in the prevention of hepatic fibrosis and hepatocellular carcinoma development
Gene expression profiling in non tumor lesion in the liver of patients prior to administering peretinoin was unrelated to the clinical outcome, however, gene expression profiling 8 weeks after starting peretinoin therapy significantly predicted the recurrence of HCC Peretinoin, a member of the acycl...
ORGANISM(S): Homo sapiens 
2012-08-19 | E-GEOD-29302 | biostudies-arrayexpress
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