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Cellular binary fate decisions require the progeny to silence genes associated with the alternative fate. The major subsets of alpha:beta T cells have been extensively studied as a model system for fate decisions. While the transcription factor RUNX3 is required for the initiation of Cd4 silencing i...
ORGANISM(S): Mus musculus (Mouse) 
2019-11-12 | PXD007511 | Pride
Comparison of Arabidopsis T87 cells transformed with an empty vector vs transcription factor (TF)-overexpressed lines of T87 cells.
ORGANISM(S): Arabidopsis thaliana 
Comparing the gene expression patterns between wild type plant (Col-0) and MYB knock-out plants.
ORGANISM(S): Arabidopsis thaliana 
Comparing the gene expression patterns between wild type plant (Col-0) and MYB Over-expression plants.
ORGANISM(S): Arabidopsis thaliana 
CRISPR-Cas9 has tremendous potential as a therapeutic tool for treating human diseases. However, prolonged expression of the nuclease and gRNA from viral vectors in an in vivo context may cause off-target activity and immunogenicity. While extracellular vesicles have been recently demonstrated to be...
ORGANISM(S): Homo Sapiens (human) 
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