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TranscriptomicsEvaluation of the effect of antimiR-122 administration on the liver, spleen and heart miRNome
To determine the effect of antimiR-122 administration on the mouse miRNome. To functionally investigate a possible link between miR-122 and iron metabolism we inhibited miR-122 by a single, intraperitoneal injection of Locked Nucleic Acid (LNA)-modified antimiR oligonucleotides into age- and sex-mat...
ORGANISM(S): Mus musculus 
2010-10-20 | E-GEOD-24786 | biostudies-arrayexpress
TranscriptomicsHypothalamic transcriptional profiling during the development of adiposity
Hypothalami from Fat (FL) and Lean lines (LL) of juvenile broiler chickens were obtained by divergent selection for high or low levels of abdominal fat at SRA-INRA, France. Gene expression patterns were measured during the development of adiposity at 1 to 7 weeks of age. Differentially expressed gen...
ORGANISM(S): Gallus gallus 
2010-05-26 | E-GEOD-10052 | biostudies-arrayexpress
TranscriptomicsTranscriptional Profiling of the Anterior Pituitary Gland of Genetically Selected Fat and Lean Chickens
Chickens divergently selected for either high abdominal fat content (fat genotype) or low abdominal fat content (lean genotype) at SRA-INRA, France were used to profile pituitary gland gene expression during juvenile development (1 to 7 weeks of age) and to identify differentially expressed genes as...
ORGANISM(S): Gallus gallus 
2011-01-13 | E-GEOD-26584 | biostudies-arrayexpress
TranscriptomicsRenal medullary genes in salt-sensitive hypertension
Substitution of chromosome 13 from Brown Norway BN/SsNHsd/Mcw (BN/Mcw) rats into the Dahl salt-sensitive SS/JrHsd/Mcw (SS/Mcw) rats resulted in substantial reduction of blood pressure salt sensitivity in this consomic rat strain designated SSBN13. In the present study, we attempted to identify genes...
ORGANISM(S): Rattus norvegicus 
2010-06-30 | E-GEOD-3608 | biostudies-arrayexpress
UnknownTGS1 mediates 2,2,7-trimethyl guanosine capping of the human telomerase RNA to direct telomerase dependent telomere maintenance.
Not available
S-EPMC9050681 | biostudies-literature
TranscriptomicsHepatic transcription profile study on European eels (Anguilla anguilla) exposed to Hg and b-sitosterol
Many enigmas surround different aspects of freshwater eel biology and life cycle. In the same way different hypothesis about why eels are disappearing from European continental waters have been proposed. One such proposal defends that poor fat accumulation of eels, due to pollution in continental wa...
ORGANISM(S): Anguilla anguilla 
2016-07-31 | E-GEOD-53344 | biostudies-arrayexpress
GenomicsPancreatic islet epigenomics reveals enhancer clusters that are enriched in Type 2 diabetes risk variants
We combined ChIP-seq of chromatin marks and key islet transcription factor with RNA-seq in human islets to map cis-regulatory networks in this primary tissue. The output of this project provides a reference map to dissect genetic variants that alter the susceptibility for Type 2 diabetes, and assist...
ORGANISM(S): Homo sapiens 
2014-01-01 | E-MTAB-1919 | biostudies-arrayexpress
TranscriptomicsAnalysis of the Haloferax volcanii Transcriptome
In this study the transcriptome of Haloferax volcanii DS70 (Wendoloski D, Ferrer C, Dyall-Smith ML. Microbiology. 2001, 147: 959-64), grown under of a variety of conditions, was mapped using a custom genome-wide tiled array consisting of 25 nt probes spaced in 35 nt windows. H. volcanii is a faculta...
ORGANISM(S): Haloferax volcanii 
2010-09-08 | E-GEOD-18066 | biostudies-arrayexpress
TranscriptomicsExpression data from Fog1+/+ and Fog1 ki/ki mouse megakaryocyte-erythroid progenitors (MEP).
The transcription co-factor FOG1 interacts with the chromatin remodeling complex NuRD to mediate gene activation and gene repression during hematopoiesis. We have generated mice with a targeted mutation in the endogenous Fog1 locus that results in an N-ternimal mutation in FOG1 that disrupts the int...
ORGANISM(S): Mus musculus 
2010-04-11 | E-GEOD-19497 | biostudies-arrayexpress
TranscriptomicsTranscriptomic response to concentrated pea root exudate
The secretion of metabolites by plant roots is a key determinant of microbial growth and colonisation. We have used Pisum sativum and its natural symbiont Rhizobium leguminosarum (it can form N2 fixing nodules on pea roots) to study the natural metabolites secreted by roots. To do this root secretio...
ORGANISM(S): Rhizobium leguminosarum 
2016-05-25 | E-MTAB-4790 | biostudies-arrayexpress
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