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TranscriptomicsmRNA profiling reveals determinants of trastuzumab efficiency in HER2-positive breast cancer
The intention was to detect genes that are determining trastuzumab efficiency in HER2-positive breast cancer cell lines with different resistance phenotypes. While BT474 should be sensitive to the drug treatment, HCC1954 is expected to be resistant due to a PI3K mutation. The cell line BTR50 has bee...
ORGANISM(S): Homo sapiens 
2015-04-21 | E-GEOD-55005 | biostudies-arrayexpress
TranscriptomicsPluripotent embryonic stem cells and multipotent adult germline stem cells reveal similar transcriptomes including pluripotency-related genes
DNA microarray analysis was performed with mouse multipotent adult germline stem cells (maGSCs) and embryonic stem cells (ESCs) from different genetic backgrounds cultured under standard ESC culture conditions and under differentiation-promoting conditions by the withdrawal of Leukemia Inhibitory Fa...
ORGANISM(S): Mus musculus 
2010-07-12 | E-GEOD-22605 | biostudies-arrayexpress
TranscriptomicsNext generation sequencing identifies differentially localized transcripts in Xenopus laevis and Xenopus tropicalis oocytes
RNA-seq technology was used to identify differentially localized transcripts from Xenopus laevis and Xenopus tropicalis stage VI oocytes. Besides the discovery of a group of novel animally enriched RNAs, this study revealed a surprisingly low conservation of vegetal RNA localization between the two ...
ORGANISM(S): Xenopus (Silurana) tropicalis 
2015-12-09 | E-GEOD-58420 | biostudies-arrayexpress
TranscriptomicsGene expression and epigenetic profiling of CD34+ hematopoietic progenitor cells in multiple sclerosis patients (expression)
Intense immunosuppression followed by autologous hematopoietic stem cell transplantation (aHSCT) is a potential treatment for patients suffering from aggressive multiple sclerosis (MS). However it remains unresolved whether autologous CD34+ hematopoietic progenitor cells of MS patients show gene exp...
ORGANISM(S): Homo sapiens 
2012-09-05 | E-GEOD-27688 | biostudies-arrayexpress
TranscriptomicsIn vitro carcinogenicity testing with Balb/c 3T3 Cells treated with various chemical carcinogens
Background: Information on the carcinogenic potential of chemicals is only availably for High Production Volume products. There is however, a pressing need for alternative methods allowing for the chronic toxicity of substances, including carcinogenicity, to be detected earlier and more reliably. He...
ORGANISM(S): Mus musculus 
2010-10-02 | E-GEOD-22180 | biostudies-arrayexpress
TranscriptomicsTranslational control in early adipogenesis
In obesity, adipose tissue expands by increasing the volume of existing adipocytes (hypertrophy), increasing the number of small adipocytes (hyperplasia) or both. Much is known about transcriptional control during adipogenesis, including early events. However, translational control plays a pivotal r...
ORGANISM(S): Mus musculus 
2012-03-28 | E-GEOD-29744 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of wildtype vs. transgenic mice expressing the cardiac specific genetically encoded FRET biosensor Epac1-PLN
3’,5’-cyclic adenosine monophosphate (cAMP) is an ubiquitous second messenger which regulates multiple physiological functions by acting in distinct subcellular microdomains. Although several targeted cAMP biosensors have been developed and used in cell lines or neonatal cardiomyocytes, it is unclea...
ORGANISM(S): Mus musculus 
2015-03-02 | E-GEOD-65651 | biostudies-arrayexpress
TranscriptomicsNon-viral generation of marmoset monkey iPS cells by a six-factor-in-one-vector approach
The analysis compares primary fibroblasts initially used for reprogramming, established marmoset ES cells and a marmoset iPS cell line which was generated witha non-viral approach using a six-factor-in-one-vector approach Cells were grown under standard conditions for marmoset pluripotent stem cell...
ORGANISM(S): Callithrix jacchus 
2015-04-08 | E-GEOD-64966 | biostudies-arrayexpress
TranscriptomicsTranscriptomic profiling of clobetasol propionate-induced immunosuppression in challenged zebrafish embryos
The aim of this experiment was to develop an approach for the assessment of immunotoxicity in zebrafish embryos (Danio rerio) using transcriptomic profiling. Clobetasol propionate, a highly potent synthetic corticosteroid, which is known to have immunosuppressive effects on vertebrates including zeb...
ORGANISM(S): Danio rerio 
2022-02-25 | E-MTAB-11092 | biostudies-arrayexpress
TranscriptomicsValproic acid achieves its anticancer activity by re-expression of cyclin D2
In this study we could show that the treatment of primary murine prostate cancer(PCa) cells derived from the well-established TRAMP (transgenic adenocarcinoma ofmouse prostate) model with the histone deacetylase inhibitor (HDI) valproic acid (VPA) has an anti-proliferative, anti-migrative and anti-i...
ORGANISM(S): Mus musculus 
2013-03-01 | E-GEOD-34072 | biostudies-arrayexpress
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