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MetabolomicsThe omics data were used to reveal the role of aaNAT1 in the salivary glands of Aedes aegypti and the changes in metabolites in the salivary glands of Aedes aegypti after blood-feeding.

The salivary glands of Aedes aegypti were collected separately from the following four groups: those injected with AaaaNAT1 dsRNA, those injected with GUS dsRNA, those after blood-feeding, and those without any treatment. Metabolomic analysis was performed on these four sample groups to...

2025-11-17 | MTBLS13324 | MetaboLights
MetabolomicsSynergistic metabolism of salivary MUC5B in oral commensal bacteria during early biofilm formation

Bacterial metabolism in oral biofilms is comprised of complex networks of nutritional chains and biochemical regulations. These processes involve both intraspecies and interspecies networks as well as interactions with components from host saliva, gingival crevicular fluid, and dietary intake. In...

2023-10-30 | MTBLS8370 | MetaboLights
MetabolomicsSalivary MUC5B Modulation of Glucose Metabolism in Early Oral Biofilms
To investigate how early mono- and dual species biofilms of oral Actinomyces naeslundii and Streptococcus gordonii clinical isolates metabolized glucose in the presence of the complex salivary mucin MUC5B, this study employed NMR-based metabolomics with interpretation of network integration. Untarge...
2024-09-11 | MTBLS10078 | MetaboLights
MetabolomicsIdentification of Salivary Lipid Biomarkers for Noninvasive Diagnosis of Reflux Esophagitis via UHPLC-MS-based Lipidomics
Introduction Reflux esophagitis (RE) is a common upper gastrointestinal disorder, and its diagnosis currently relies primarily on invasive endoscopic examination. The lack of reliable non-invasive biomarkers substantially limits early detection and large-scale screening. Saliva represents a promisin...
2026-03-31 | MTBLS14198 | MetaboLights
MetabolomicsSalivary Multi-omics Characterization and Staging Diagnostic Model for Type 2 Diabetes with Different Stages of Periodontitis

Background: This study aims to comprehensively characterize the dynamic succession of the salivary microbiome and metabolic reprogramming in type 2 diabetes mellitus (T2DM) patients across progressive stages of periodontitis (Stage I–IV) using an integrated multi-omics approach. We specifica...

2026-05-20 | MTBLS13827 | MetaboLights
TranscriptomicsTranscriptomic and functional analysis of the Anopheles gambiae salivary gland in relation to blood feeding
Background: The Anopheles gambiae salivary glands play a major role in malaria transmission and express a variety of bioactive components that facilitate blood-feeding by preventing platelet aggregation, blood clotting, vasodilatation, and inflammatory and other reactions at the probing site on the ...
ORGANISM(S): Anopheles gambiae 
2011-11-01 | E-GEOD-33385 | biostudies-arrayexpress
TranscriptomicsAtlas of Gene Expression at Microanatomical Resolution of the Submandibular Salivary Gland
The goal of this study was to generate a spatiotemporal atlas of gene expression in the developing salivary gland. This will allow us to identify changes in gene expression that may result in the formation of the different domains of the salivary gland. At least 4 microarrays per location per time ...
ORGANISM(S): Mus musculus 
2011-07-01 | E-GEOD-22828 | biostudies-arrayexpress
TranscriptomicsHigh throughput sequencing of B.henselae infected and non-infected I. ricinus salivary glands
In order to select genes that are differentially expressed in salivary glands during Ixodes ricinus infection by Bartonella henselae we compare the transcriptome of infected and non-infected salivary glands I. ricinus from a pathogen free colony were infected -or not- with B. henselae at the larval ...
ORGANISM(S): Ixodes ricinus 
2015-04-02 | E-GEOD-56746 | biostudies-arrayexpress
ProteomicsCross-sectional association of salivary proteins with age, sex, body mass index, smoking, and education
In a cross-sectional approach, we analyzed the influence of age, sex, body mass index (BMI), smoking, and education on salivary protein signatures in whole saliva samples of 187 individuals. Subjects were randomly selected from the population-based Study of Health in Pomerania (SHIP-Trend).
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-03-13 | MSV000083569 | MassIVE
TranscriptomicsSingle cell RNA-sequencing of epithelial cells, endothelial cells and macrophages from mouse submandibular salivary glands
The salivary glands often become damaged in individuals receiving radiotherapy for head and neck cancer, resulting in chronic dry mouth. This leads to detrimental effects on their health and quality of life, for which there is no regenerative therapy. Macrophages are the predominant immune cell in t...
ORGANISM(S): Mus musculus 
2023-10-01 | E-MTAB-13374 | biostudies-arrayexpress
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