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Identification of downstream targets and pathways initiated by Sall1 and Nanog during reprogramming
To study the function of SUMOylation and SUMO-SIM interactions for particular substrates poses several challenges. SUMOylation occurs transiently and often in a small percentage of the total copy numbers of a given substrate. Modified proteins can be readily deSUMOylated and SUMO can be recycled and...
ORGANISM(S): Homo sapiens (Human) 
2021-09-21 | PXD021923 | Pride
SALL1 enforces microglia-specific DNA binding and function of SMADs to establish microglia identity [3D]
This experiment was carried to identify potential reprogramming factors that augment Sall1 and Nanog reprogramming efficiency either individually or in combination during co-expression. The intent of the experiment was to understand genes regulated by Sall1 and Nanog during mouse epiblast stem cell ...
ORGANISM(S): Mus musculus 
Sall1 is a multi-zinc finger transcription factor that regulates kidney organogenesis. It is considered to be a transcriptional repressor, preferentially localized on heterochromatin. Mutations or deletions of the human SALL1 gene are associated with the Townes-Brocks syndrome. Despite its high expr...
ORGANISM(S): Mus musculus 
2010-11-23 | GSE25523 | GEO
Co-option of the transcription factor SALL1 in mole ovotestis formation [4C]
SALL1 enforces microglia-specific DNA binding and function of SMADs to establish microglia identity [RNA-seq]
SALL1 enforces microglia-specific DNA binding and function of SMADs to establish microglia identity [ChIP-seq]
SALL1 enforces microglia-specific DNA binding and function of SMADs to establish microglia identity [ATAC-seq]
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