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UnknownSALL4: An Intriguing Therapeutic Target in Cancer Treatment.
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S-EPMC9406946 | biostudies-literature
ProteomicsTargeting transcription factors through an IMiD independent zinc finger domain
Immunomodulatory imide drugs (IMiDs) degrade specific C2H2 zinc finger degrons in transcription factors, making them effective against certain cancers. SALL4, a cancer driver, contains seven C2H2 zinc fingers in three clusters, including an IMiD degron in zinc finger cluster one (ZFC1). Surprisingly...
ORGANISM(S): Homo sapiens (Human) 
2025-06-23 | PXD061151 | Pride
Human Sall4 degrader Hcc model Sh6 
TranscriptomicsExpression analysis of OSK and Sall4+OSK reprogramming cells sorted for expression of miR-290 and/or miR-302.
MEFs were infected with Oct4, Sox2, Klf4 (+/- Sall4), sorted for miR-290/302 reporter expression at day 9 (OSK) or 12 (Sall4+OSK), and then profiled. Resulting iPSCs were also profiled. Mouse ES cells were differentiated and sorted for miR-290/302 reporter expression during Fgf/Activin differentiati...
ORGANISM(S): Mus musculus 
2014-03-31 | E-GEOD-54341 | biostudies-arrayexpress
GenomicsMeDIP-seq of pig induced pluripotent stem cells
The wide application of pig disease model has caused a surge of interest in the study of derivation of pig induced pluripotent cells (iPSCs). Here we performed genome-wide analysis of gene expression profiling by RNA-seq and small RNA-seq and DNA methylation profile by MeDIP-seq in pig iPSCs through...
ORGANISM(S): Sus scrofa 
2016-01-07 | E-MTAB-2643 | biostudies-arrayexpress
TranscriptomicsmiRNA profiling analysis of pig induced pluripotent stem cells by high-throughput sequencing
The wide application of pig disease model has caused a surge of interest in the study of derivation of pig induced pluripotent cells (iPSCs). Here we performed genome-wide analysis of gene expression profiling by RNA-seq and small RNA-seq and DNA methylation profile by MeDIP-seq in pig iPSCs through...
ORGANISM(S): Sus scrofa 
2015-05-08 | E-MTAB-2631 | biostudies-arrayexpress
TranscriptomicsComprehensive transcriptome analysis of pig induced pluripotent stem cells by high-throughput sequencing
The wide application of pig disease model has caused a surge of interest in the study ofderivation of pig induced pluripotent cells (iPSCs). Here we performed genome-wide analysis of gene expression profiling by RNA-seq and small RNA-seq and DNA methylation profile by MeDIP-seq in pig iPSCs through ...
ORGANISM(S): Sus scrofa 
2015-09-17 | E-MTAB-2634 | biostudies-arrayexpress
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