Sort   by:  
 Page size 
UnknownHigh-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations.
The impact of somatic structural variants (SVs) on gene expression in cancer is largely unknown. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole-genome sequencing data and RNA sequencing from a common set of 1220 cancer cases, we report ...
S-EPMC7002524 | biostudies-literature
GenomicsEGAS00001000165-sc-20150427 - samples
Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells
EGAD00001001353 | EGA
GenomicsEGAS00001000902-sc-20150424 - samples
Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells
EGAD00001001351 | EGA
GenomicsEGAS00001000160-sc-20150424 - samples
Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells
EGAD00001001349 | EGA
GenomicsFrequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells
Mitochondrial genomes are separated from the nuclear genome for most of the cell cycle by the nuclear double membrane, intervening cytoplasm and the mitochondrial double membrane. Despite these physical barriers we show that somatically acquired mitochondrial-nuclear genome fusion sequences are pres...
EGAS00001001234 | EGA
UnknownPregnancy outcomes and vaccine effectiveness during the period of omicron as the variant of concern, INTERCOVID-2022: a multinational, observational study.

Background

In 2021, we showed an increased risk associated with COVID-19 in pregnancy. Since then, the SARS-CoV-2 virus has undergone genetic mutations. We aimed to examine the effects on maternal and perinatal outcomes of COVID-19 during pregnancy, and evaluate vaccine effectiveness, when o...
S-EPMC9910845 | biostudies-literature
Transcriptomics21 Breast Cancer Genome Affymetrix SNP6 Array Data
Cancer evolves dynamically, as clonal expansions supersede or overlap one another, driven by shifting selective pressures, mutational processes and disrupted cancer genes. These processes mark the genome, such that a cancerÕs life history is encrypted in the timing, ploidy, clonality and patterns of...
ORGANISM(S): Homo sapiens 
2012-06-16 | E-MTAB-1087 | biostudies-arrayexpress
UnknownPrenatal evaluation, diagnosis and management of fetal corpus callosal abnormalities: international Delphi consensus.

Objective

The corpus callosum (CC) is an interhemispheric structure that facilitates communication between the two cerebral hemispheres. Anomalies of the CC are frequent and associated with a wide spectrum of altered neurodevelopmental outcomes. However, variability in diagnostic criteria an...
S-EPMC12579776 | biostudies-literature
UnknownMutational processes molding the genomes of 21 breast cancers.
All cancers carry somatic mutations. The patterns of mutation in cancer genomes reflect the DNA damage and repair processes to which cancer cells and their precursors have been exposed. To explore these mechanisms further, we generated catalogs of somatic mutation from 21 breast cancers and applied ...
S-EPMC3414841 | biostudies-literature
UnknownHow COVID-19 Treatment in Pregnancy Reflects Healthcare Utilization During a Pandemic: A Two-Stage Individual Participant Data Meta-Analysis Combining Case-Based Registries.

Purpose

To describe an international response to the COVID-19 pandemic by estimating the prevalence of medication use for COVID-19 treatment in pregnancy, stratified by hospitalization, trimester of pregnancy, and country.

Methods

We conducted a two-stage individual participant data m...
S-EPMC12418691 | biostudies-literature
Sort   by:  
 Page size