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TranscriptomicsAdipocyte Differentiation of Immortalized Human Bone Marrow-derived Stromal Cells is Modulated by microRNA-155, microRNA-221 and microRNA-222
Human bone marrow mesenchymal stromal cells are capable of limited self-renewal and multi-lineage differentiation in vitro. Several studies have demonstrated that microRNAs, post-transcriptional modifiers of protein expression, play crucial roles in the regulation of these complex processes. To gain...
ORGANISM(S): Homo sapiens 
2011-08-22 | E-GEOD-24898 | biostudies-arrayexpress
UnknownA CNTNAP1 Missense Variant Is Associated with Canine Laryngeal Paralysis and Polyneuropathy.
Laryngeal paralysis associated with a generalized polyneuropathy (LPPN) most commonly exists in geriatric dogs from a variety of large and giant breeds. The purpose of this study was to discover the underlying genetic and molecular mechanisms in a younger-onset form of this neurodegenerative disease...
S-EPMC7761076 | biostudies-literature
UnknownThe nuclear structural protein NuMA is a negative regulator of 53BP1 in DNA double-strand break repair.
P53-binding protein 1 (53BP1) mediates DNA repair pathway choice and promotes checkpoint activation. Chromatin marks induced by DNA double-strand breaks and recognized by 53BP1 enable focal accumulation of this multifunctional repair factor at damaged chromatin. Here, we unveil an additional level o...
S-EPMC6451129 | biostudies-literature
UnknownHidden fungal diversity from the Neotropics: Geastrum hirsutum, G. schweinitzii (Basidiomycota, Geastrales) and their allies.
Taxonomy of Geastrum species in the neotropics has been subject to divergent opinions among specialists. In our study, type collections were reassessed and compared with recent collections in order to delimit species in Geastrum, sect. Myceliostroma, subsect. Epigaea. A thorough review of morphologi...
S-EPMC6364924 | biostudies-literature
UnknownAntibodies for β2-Microglobulin and the Heavy Chains of HLA-E, HLA-F, and HLA-G Reflect the HLA-Variants on Activated Immune Cells and Phases of Disease Progression in Rheumatoid Arthritis Patients under Treatment.
Rheumatoid arthritis (RA) is a progressive, inflammatory, autoimmune, symmetrical polyarticular arthritis. It is characterized by synovial infiltration and activation of several types of immune cells, culminating in their apoptosis and antibody generation against "altered" autoantigens. β2-microglob...
S-EPMC10123671 | biostudies-literature
UnknownEight millennia of continuity of a previously unknown lineage in Argentina.
The central Southern Cone of South America was one of the last regions of the globe to become inhabited by people1, and remains under-represented in studies of ancient DNA. Here we report genome-wide data from 238 ancient individuals spanning ten millennia. The oldest, from the Pampas reg...
S-EPMC12747222 | biostudies-literature
UnknownOngoing declines for the world's amphibians in the face of emerging threats.
Systematic assessments of species extinction risk at regular intervals are necessary for informing conservation action1,2. Ongoing developments in taxonomy, threatening processes and research further underscore the need for reassessment3,4. Here we report the findings of the se...
S-EPMC10567568 | biostudies-literature
UnknownFungal Planet description sheets: 951-1041.
Not available
S-EPMC7085856 | biostudies-literature
UnknownMammal responses to global changes in human activity vary by trophic group and landscape.
Wildlife must adapt to human presence to survive in the Anthropocene, so it is critical to understand species responses to humans in different contexts. We used camera trapping as a lens to view mammal responses to changes in human activity during the COVID-19 pandemic. Across 163 species sampled in...
S-EPMC11090811 | biostudies-literature
UnknownA multi-layer functional genomic analysis to understand noncoding genetic variation in lipids.
A major challenge of genome-wide association studies (GWASs) is to translate phenotypic associations into biological insights. Here, we integrate a large GWAS on blood lipids involving 1.6 million individuals from five ancestries with a wide array of functional genomic datasets to discover regulator...
S-EPMC9388392 | biostudies-literature
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