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ProteomicsAn unusual dual sugar-binding lectin domain controls the substrate specificity of a mucin-type O-glycosyltransferase
N-acetylgalactosaminyl transferases (GalNAc-Ts) initiate mucin-type O-glycosylation, an abundant and complex post-translational modification that regulates host-microbe interactions, tissue development, and metabolism. GalNAc-Ts contain a C-terminal lectin domain consisting of three homologous repea...
ORGANISM(S): Homo sapiens (Human) 
2024-05-23 | PXD047845 | Pride
Muc1 O-glycosylation Structure Lectin domain Substrate specificity 
ProteomicsShared and Distinct Mechanisms of UBA1 Inactivation Across Different Diseases
UBA1 initiates most cellular ubiquitin signaling by activating and transferring ubiquitin to tens of E2 enzymes. Clonally acquired UBA1 missense mutations cause a severe inflammatory-hematologic overlap disease called VEXAS (vacuoles, E1, X-linked autoinflammatory, somatic) syndrome. Despite extensi...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000092914 | MassIVE
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