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TranscriptomicsS-allylmercaptocysteine Improves NAFLD by Enhancing AhR/Nrf2-mediated Drug Metabolising Enzymes and Reducing NF-κB/IκBα and NLRP3/6-mediated Inflammation
We investigated the novel molecular mechanisms of the antioxidant and anti-inflammatory properties of S-allylmercaptocysteine (SAMC) based on a transcriptomic study in a non-alcoholic fatty liver disease (NAFLD) rat model. NAFLD was induced in Sprague-Dawley rats by feeding with a high fat diet (HFD...
ORGANISM(S): Rattus norvegicus 
2020-07-20 | GSE150841 | GEO
ProteomicsInhibitory effect of S-Allylmercaptocysteine on TLR4-mediated inflammation in mammary epithelial cells
Mastitis is an inflammatory disease and negatively affects milk quality and quantity. S-Allylmercaptocysteine (SAMC) inhibits the LPS-induced production of IL-6 and activation of nuclear factor kappaB p65 subunit in cultured mammary epithelial HC11 cells. The global phosphoproteomic analysis reveale...
ORGANISM(S): Mus Musculus (mouse) 
2025-01-09 | PXD048365 | JPOST Repository
UnknownGarlic-derived compound S-allylmercaptocysteine inhibits hepatocarcinogenesis through targeting LRP6/Wnt pathway.
Not available
S-EPMC6090075 | biostudies-literature
UnknownS-Allylmercaptocysteine improves alcoholic liver disease partly through a direct modulation of insulin receptor signaling.
Not available
S-EPMC7982498 | biostudies-literature
UnknownS-allylmercaptocysteine inhibits TLR4-mediated inflammation through enhanced formation of inhibitory MyD88 splice variant in mammary epithelial cells.
Not available
S-EPMC11604973 | biostudies-literature
UnknownS-allylmercaptocysteine inhibits mucin overexpression and inflammation via MAPKs and PI3K-Akt signaling pathways in acute respiratory distress syndrome.
Not available
S-EPMC7305891 | biostudies-literature
ProteomicsLoss of the Mitochondrial SAM Transporter Reveals a Lipoylation-Dependent Metabolic Vulnerability in the Postnatal Heart
SLC25A26 encodes the sole mitochondrial S-adenosylmethionine carrier (SAMC). Inside mitochondria, SAM functions as a methyl group donor for various methyltransferases and as a substrate for radical SAM enzymes. Variants in SAMC are associated with mitochondrial disease, and we previously demonstrate...
ORGANISM(S): Mus musculus (Mouse) 
2026-07-03 | PXD050486 | Pride
GenomicsS-allylmercaptocysteine Improves NAFLD by Enhancing AhR/Nrf2-mediated Drug Metabolising Enzymes and Reducing NF-κB/IκBα and NLRP3/6-mediated Inflammation
S-allylmercaptocysteine Improves NAFLD by Enhancing AhR/Nrf2-mediated Drug Metabolising Enzymes and Reducing NF-κB/IκBα and NLRP3/6-mediated Inflammation
PRJNA633839 | ENA
UnknownNatural thioallyl compounds increase oxidative stress resistance and lifespan in Caenorhabditis elegans by modulating SKN-1/Nrf.
Not available
S-EPMC4761942 | biostudies-literature
ProteomicsThe mitochondrial methylome is evolutionary conserved and regulated by cytosolic SAM
S-adenosylmethionine (SAM) is the principle biological methyl group donor for a diverse range of substrates. It is synthesised in the cytosolic methionine cycle and shuttled throughout the cell. The mitochondrial SAM (mitoSAM) pool depends on import through the inner-membrane SAMC and supports the m...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) Drosophila melanogaster (Fruit fly) 
2021-02-22 | PXD019494 | Pride
Mitochondria Prm Human Mouse Methylation Drosophila 
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