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MetabolomicsExploring the effects of acupuncture intervention on the gut microbiota of SAMP8 mice, a model of Alzheimer's disease.

Exploring the effects of acupuncture intervention on the gut microbiota of SAMP8 mice, a model of Alzheimer's disease.

2026-02-26 | MTBLS13601 | MetaboLights
TranscriptomicsIn vitro caloric restriction induces protective genes and functional rejuvenation in senescent SAMP8 astrocytes
Astrocytes are key cells in brain aging, helping neurons to undertake healthy aging or otherwise letting them enter into a spiral of neurodegeneration. We aimed to characterize astrocytes cultured from senescence-accelerated prone 8 (SAMP8) mice, a mouse model of brain pathological aging, along with...
ORGANISM(S): Mus musculus 
2015-06-23 | E-GEOD-60388 | biostudies-arrayexpress
TranscriptomicsEffects of AβPP Antisense Treatment on Hippocampal Gene Expression in Adult Mice with Memory Deficits
The purpose of this study was to determine the effect of peripheral (IV) administration of AβPP antisense on hippocampal gene expression as well as on learning and memory as measured by T-maze in adult male mice aged 12 months. The AβPP antisense treatment reversed learning and memory deficits and ...
ORGANISM(S): Mus musculus 
2015-02-13 | E-GEOD-65877 | biostudies-arrayexpress
TranscriptomicsHippocampal Gene Expression in Young and Adult Mice with Memory Deficits
The purpose of this study was to determine whether there were differences in gene expression in the hippocampus, a part of the brain involved in memory consolidation, between male mice with age-related memory deficits (SAMP8 mice) and control mice with no age-related memory deficits. The senescence...
ORGANISM(S): Mus musculus 
2013-08-30 | E-GEOD-49699 | biostudies-arrayexpress
GenomicsMus musculus strain:SAMP8 and SAMR1
Mus musculus strain:SAMP8 and SAMR1 Transcriptome or Gene expression
PRJNA735929 | ENA
GenomicsMus musculus strain:SAMP8 and SAMR1
Mus musculus strain:SAMP8 and SAMR1 Transcriptome or Gene expression
PRJNA387643 | ENA
ProteomicsSex-specific molecular hallmarks of atherogenesis susceptibility in senescence-accelerated mice
The senescence-accelerated mouse (SAM) model has been extensively used to study neurological alterations associated with aging. Although the SAM model is also useful to study vascular aging, there is still work to be done to better define its utility as a model of atherosclerosis, since contradictor...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-02 | PXD057104 | Pride
Calcification Lipid metabolism. Extracellular vesicles Aging Atherosclerosis Senescence 
GenomicsHippocampus of SAMR1 and SAMP8 mice [mRNA]
Hippocampus of SAMR1 and SAMP8 mice [mRNA]
PRJNA498406 | ENA
GenomicsHippocamus of SAMR1 and SAMP8 mice [microRNA]
Hippocamus of SAMR1 and SAMP8 mice [microRNA]
PRJNA498411 | ENA
ProteomicsThe proteomic analysis of SAMR1 and SAMP8 hippocampi and serum
We performed proteomic analysis of serum and hippocampal tissue from senescence-accelerated mouse-prone 8 (SAMP8) and senescence-accelerated mouse-resistant 1 (SAMR1) mice.
ORGANISM(S): Mus Musculus (mouse) 
2026-01-19 | PXD066582 | JPOST Repository
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