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TranscriptomicsMolecular Insight into the Association between Cartilage Regeneration and Ear Wound Healing in Genetic Mouse Models: Targeting New Genes in Regeneration
Certain mouse strains have the ability to heal both ear wounds and knee articular cartilage injuries. A positive genetic correlation between cartilage healing and protection from osteoarthritis exists, which suggests that a common core of genes may operate in healing process. Here, we analyzed knee...
ORGANISM(S): Mus musculus 
2013-07-04 | E-GEOD-48505 | biostudies-arrayexpress
TranscriptomicsAdult Human Chondrocyte Response to IL-1B
IL-1B is an important cytokine that is often found to be up-regulated during osteoarthritic and rheumatoid joint diseases. It is viewed as a catabolic factor, inducing enzymes that allow for the degradation of the cartilage extracellular matrix and also has essential roles as an autocrine and parac...
ORGANISM(S): Homo sapiens 
2008-05-14 | E-GEOD-11427 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of cartilage gene expression in response to cartilage-specific ablation of Site-1 protease (Mbtps1) in mice (S1Pcko mice)
Analysis of differential gene expression in chondrocytes due to S1P ablation in mice. The hypothesis tested in this study was that ablation of S1P in mice would result in differential gene expression in chondrocytes that may be responsible for the S1Pcko phenotype. The chondroepiphyseal cartilage fr...
ORGANISM(S): Mus musculus 
2014-07-31 | E-GEOD-55577 | biostudies-arrayexpress
TranscriptomicsTranscript Expression Changes over Time-from-injury in Anterior Cruciate Ligament Tears: Implications for Reconstruction and Repair
The anterior cruciate ligament (ACL) is an essential stabilizer of the tibiofemoral articulation. ACL tears often lead to functional instability and are associated with an increased risk for osteoarthritis. The healing potential of the injured ACL is poorly understood and is considered to be limited...
ORGANISM(S): Homo sapiens 
2014-09-13 | E-GEOD-61385 | biostudies-arrayexpress
TranscriptomicsRNA-seq and Microarray in Transcriptome Profiling of Anterior Cruciate Ligament Tears: Implications for Prognostic Biomarkers Discovery
Injury to anterior cruciate ligament (ACL) is common in young individuals and a frequent cause of functional instability and early onset of osteoarthritis. The healing potential of an injured ACL is known to decay over time. The molecular origin of this healing deficiency largely remains elusive but...
ORGANISM(S): Homo sapiens 
2015-01-30 | E-GEOD-65469 | biostudies-arrayexpress
TranscriptomicsGenetic Loci that Regulate Ectopic Calcification in Response to Knee Trauma in LG/J by SM/J Advanced Intercross Mice
Ectopic calcification in synovial tissues is devastating to diarthrodial joints. While some forms of synovial ectopic calcification have genetically simple basis, most cases manifest as complex traits with environmental and multigenic components. The location of causal loci or the physiological proc...
ORGANISM(S): Mus musculus 
2015-01-09 | E-GEOD-64793 | biostudies-arrayexpress
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