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TranscriptomicsIdentification of Sox9-Regulated Pathways During Early Pancreas Organogenesis
Sox9 target genes were identified by comparing gene expression in Sox9-ablated versus wild-type pancreata using microarray analysis. Sox9 was conditionally ablated in the developing pancreas via recombination of a Sox9-flox allele (Kist et al., 2002) using the Pdx1-Cre transgene (Gu et al., 2002). T...
ORGANISM(S): Mus musculus 
2012-08-01 | E-GEOD-28669 | biostudies-arrayexpress
TranscriptomicsIdentification of Sox9-Regulated Pathways During the Secondary Transition Stage of Pancreas Development
Sox9 target genes were identified during the secondary transition stage of pancreas development by comparing gene expression in Sox9-ablated versus wild-type pancreata using microarray analysis. Sox9 was conditionally ablated during the secondary transition in the developing pancreas via recombinati...
ORGANISM(S): Mus musculus 
2012-08-01 | E-GEOD-28670 | biostudies-arrayexpress
TranscriptomicsTranscriptional and epigenetic profiling of the progression of hESCs to beta cells
To characterize the epigenetic programs that underlie pancreas differentiation, we have generated genome-scale maps of H3K4me and H3K27me3 patterns by ChIP-seq and determined expression profiles by RNA-seq from undifferentiated human ESCs, four intermediate differentiated stages (definitive endoderm...
ORGANISM(S): Homo sapiens 
2013-02-08 | E-MTAB-1086 | biostudies-arrayexpress
TranscriptomicsExpression data of Sox9+ and Ngn3+ mouse pancreas cells at different stages of development
Genes specific to Sox9+ pancreatic progenitors were identified by comparing the gene expression in embryonic and adult Sox9+ cells. We used microarray analysis to detail the global changes in gene expression as Sox9 positive embryonic pancreatic progenitors differentiatiate into adult ductal cells o...
ORGANISM(S): Mus musculus 
2012-08-01 | E-GEOD-34060 | biostudies-arrayexpress
TranscriptomicsIdentification of Nkx6.1 regulated genes in mature pancreatic islets.
Nkx6.1 target genes were identified in mature pancreatic islets by comparing gene expression in conditional Nkx6.1-ablated islets versus control islets using microarray analysis. Nkx6.1 was conditionally ablated in mature pancreatic islets by recombination of a Nkx6.1-flox allele using the tamoxifen...
ORGANISM(S): Mus musculus 
2013-09-12 | E-GEOD-40470 | biostudies-arrayexpress
GenomicsGenome-wide measurement of Nkx-6.1 in mouse islets.
We perfomed a ChIP-seq experiment to identify the location of binding sites for the transcription factor Nkx6-1 in mouse islets. A single set of islets were extracted from a mouse and Nkx-6.1 and input ChIP-Seq libraries were prepared and sequenced.
ORGANISM(S): Mus musculus 
2013-09-12 | E-GEOD-40975 | biostudies-arrayexpress
TranscriptomicsTestis-to-ovary reprogramming and testis regression after ablation of Sox9 in Sox8-/- mice
We used two Sertoli-cell-specific Cre lines: Wt1-CreERT2 and Sox9-CreERT2, to induce Sox9 ablation on a Sox8 -/- background in the adult testis. Sox9/8 double KO testes undergo testis-to-ovary genetic reprogramming and Sertoli-to-granulosa cell transdifferentiation.
ORGANISM(S): Mus musculus 
2016-06-08 | E-MTAB-4572 | biostudies-arrayexpress
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