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MetabolomicsMultiomic profiling of iron-deficient infant monkeys reveals alterations in neurologically important biochemicals in serum and cerebrospinal fluid before the onset of anemia

The effects of iron deficiency (ID) during infancy extend beyond the hematologic compartment and include short- and long-term adverse effects on many tissues including the brain. However, sensitive biomarkers of iron-dependent brain health are lacking in humans. To determine whether serum and cer...

2022-07-12 | MTBLS3388 | MetaboLights
ProteomicsMatched Lung Tumor And Emphysematous Matrix Proteomics, Transcriptomics, and Translatomics
Chronic obstructive pulmonary disease (COPD) is a known risk factor for developing lung cancer suggesting that the COPD stroma contains factors supporting tumorigenesis. Since cancer initiation is complex we used a multi-omic approach to identify gene expression patterns that distinguish COPD stroma...
ORGANISM(S): Homo sapiens (Human) 
2019-05-28 | PXD007919 | Pride
Translatomics Copd Lung cancer Data integration Transcriptomics Rna Jive Proteomics Emphysema 
ProteomicsTwo cancer-promoting stromal gene expression programs depend on lung function
Chronic obstructive pulmonary disease (COPD) is an independent risk factor for lung cancer, suggesting that COPD stroma favors cancer initiation. Therefore, we used proteomics and polysome-profiling to identify gene expression programs that distinguish stroma of patients harboring lung cancer from t...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD007743 | Pride
Human Translatomics Copd Lung tissue Transcriptomics Proteomics Emphysema Lung cancer 
ProteomicsMultiomic Profiling of Iron Deficient Infant Monkeys Reveals Alterations in Neurologically Important Biochemicals in Serum and CSF Prior to the Onset of Anemia
Background: The effects of iron deficiency anemia (IDA) during infancy extend beyond the hematologic compartment and include short- and long-term adverse effects on many tissues including the brain. However, biomarkers of iron-dependent brain health are lacking in humans. Prior analyses in rhesus in...
ORGANISM(S): Macaca mulatta (Rhesus macaque) 
2022-03-18 | PXD028275 | Pride
Infancy Lc-msms Proteomics Acute phase Metabolomics Monkey Tmt Serum Csf Neurological function Iron deficiency anemia Synaptogenesis 
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