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TranscriptomicsDepletion of murine intestinal microbiota: effects on gut mucosa and epithelial gene expression
Inappropriate cross talk between mammals and their gut microbiota may trigger intestinal inflammation and drive extra-intestinal immune-mediated diseases. Studies with germ-free or gnotobiotic animals represent the gold standard for research on bacterial-host interaction but they are not readily acc...
ORGANISM(S): Mus musculus 
2011-08-14 | E-GEOD-22648 | biostudies-arrayexpress
TranscriptomicsAltered mucosal homeostasis in mice lacking secretory antibodies
The mammalian gut is inhabited by a large and complex microbial community that lives in a mutualistic relationship with its host. Innate and adaptive mucosal defense mechanisms ensure a homeostatic relationship with this commensal microbiota. Secretory antibodies are generated from the active polyme...
ORGANISM(S): Mus musculus 
2013-12-28 | E-GEOD-34630 | biostudies-arrayexpress
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