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UnknownHepatocyte-Macrophage Acetoacetate Shuttle Protects against Tissue Fibrosis.
Not available
S-EPMC6559243 | biostudies-literature
TranscriptomicsInterferon-gamma Induced Gene Expression Changes in Human Neutrophils
The cytokine interferon-gamma (IFN-gamma) is used as a drug to treat Chronic Granulomatous Disease (CGD), a group of genetic disorders characterized by defects in components of the neutrophil-resident NADPH oxidase/Nox2 enzyme system. Administration of IFN-gamma to these patients results in decreas...
ORGANISM(S): Homo sapiens 
2018-12-14 | E-MTAB-7261 | biostudies-arrayexpress
ProteomicsMitochondrial Protein Hyperacetylation in the Failing Heart
Mitochondrial proteomics was used to identify energy metabolic derangements that occur during the early stages of heart failure in well-defined mouse models. Levels of β-hydroxybutyrate dehydrogenase 1 (BDH1), a key enzyme in ketone oxidation, was upregulated. 13C-substrate flux studies and metabol...
ORGANISM(S): Mus musculus (Mouse) 
2016-02-26 | PXD001652 | Pride
Heart failure Acetylation Mitochondria 
MetabolomicsLongitudinal Deep Multi-Omics Profiling in aCLN3Δex7/8Minipig Model Reveals Novel Biomarker Signatures for Batten Disease
Development of therapies for CLN3 Batten disease, a rare pediatric lysosomal storage disorder, has been hindered by the lack of etiological insights and translatable biomarkers to clinics. Here, we used a deep multi-omics approach to discover new biomarkers using longitudinal serum samples from a po...
2025-08-13 | MTBLS1107 | MetaboLights
UnknownDroplet-based forward genetic screening of astrocyte-microglia cross-talk.
Not available
S-EPMC10066924 | biostudies-literature
UnknownThe Transcription Factor STAT6 Mediates Direct Repression of Inflammatory Enhancers and Limits Activation of Alternatively Polarized Macrophages.
Not available
S-EPMC5772169 | biostudies-literature
UnknownALG8-CDG: Molecular and phenotypic expansion suggests clinical management guidelines.
Not available
S-EPMC9474684 | biostudies-literature
UnknownTranscriptional regulation of macrophage cholesterol efflux and atherogenesis by a long noncoding RNA.
Not available
S-EPMC5839972 | biostudies-literature
UnknownALG13 X-linked intellectual disability: New variants, glycosylation analysis, and expanded phenotypes.
Not available
S-EPMC8720508 | biostudies-literature
UnknownA 2-Year Randomized Controlled Trial of Human Caloric Restriction: Feasibility and Effects on Predictors of Health Span and Longevity.
Not available
S-EPMC4841173 | biostudies-literature
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