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TranscriptomicsAmniotic fluid and necrotizing enterocolitis in preterm pigs
Preterm neonates are susceptible to gastrointestinal (GI) disorders such as necrotizing enterocolitis (NEC). Maternal milk, and especially colostrum, protects against NEC via growth promoting, immunomodulatory and antimicrobial factors. The fetal enteral diet, amniotic fluid (AF), contains similar b...
ORGANISM(S): Sus scrofa 
2010-05-06 | E-GEOD-13515 | biostudies-arrayexpress
TranscriptomicsTemporal development of necrotizing enterocolitis in the preterm pig
Necrotizing enterocolitis (NEC), a serious gastrointestinal disease that afflicts 5-10% of preterm infants, often progresses rapidly from mild food intolerance into extensive haemorrhage, inflammation and necrosis. Events leading to NEC have remained poorly defined. Similar disease characteristics a...
ORGANISM(S): Sus scrofa 
2010-05-07 | E-GEOD-13516 | biostudies-arrayexpress
ProteomicsData in support of plasma proteomics study forearly markers of antibiotics dependent necrotising enterocolitis in preterm pigs
Most hospitalized preterm infants receive antibiotics (AB) in the first days of life to treat or prevent systemic infections. Short-term, early AB treatment may also prevent against the microbiota-dependent serious gut disorder, necrotising enterocolitis (NEC). However, it remains a challenge to pre...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2021-09-08 | PXD015938 | Pride
Antibiotics Nec Plasma Pig 
ProteomicsData in support ofRapid proteome changes in plasma and cerebrospinal fluid following bacterial infection in preterm newborn pigs
Background: Neonatal infection and sepsis are common for preterm infants due to their immature immune system. Early diagnosis is important for effective treatment but few early markers of systemic and neuro-inflammatory responses in neonates are known. We hypothesized that systemic infection with Gr...
ORGANISM(S): Homo sapiens (Human) Sus scrofa domesticus (domestic pig) 
2020-05-26 | PXD016013 | Pride
Csf Proteomics Sepsis Pig 
ProteomicsData in support of nutrition for improved growth and health of very preterm infants
Impaired growth and nutrition after preterm birth is associated with morbidities and poor neurodevelopmental outcome, but it is not clear whether this reflects causal relationships. To improve growth, human milk is often fortified with protein, energy and minerals, providing small, but significant, ...
ORGANISM(S): Homo sapiens (Human) 
2025-11-27 | PXD053348 | Pride
Neonate Necrotizing enterocolitis Proteomics Colostrum Milk 
ProteomicsData in support of Circulating neutrophil extracellular trap components including cell-free DNA are associated with neonatal sepsis and necrotizing enterocolitis in newborn, immature infants, pigs and mice
Preterm infants are highly susceptible to late-onset sepsis (LOS) and necrotizing enterocolitis (NEC) but specific biomarkers for diagnosis and effective treatment are lacking. Neutrophil extracellular traps (NETs) are related to sepsis in adults but not investigated in infant conditions. This is th...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2018-03-05 | PXD004082 | Pride
Necrotizing enterocolitis Preterm neonates Sepsis Neutrophil extracellular traps 
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