Proteomics

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Data in support of nutrition for improved growth and health of very preterm infants

ABSTRACT: Impaired growth and nutrition after preterm birth is associated with morbidities and poor neurodevelopmental outcome, but it is not clear whether this reflects causal relationships. To improve growth, human milk is often fortified with protein, energy and minerals, providing small, but significant, fortification-induced gains in body weight, length and/or head circumference. the effect of Bovine Colostrum fortification on AAs and proteins in plasma, and how fortification-induced AA changes during the first two weeks of fortification associated with changes in anthropometric measures, gestational age (GA) at birth, birth weight, key morbidities (BPD, ROP, LOS) and IGF-1 levels. Collectively, the analyses shed light on the complex interplay between fortification-induced changes to plasma AA/protein levels and the growth and morbidities in very preterm infants fed fortified human milk.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Plasma

DISEASE(S): Infantile Onset

SUBMITTER: Allan Stensballe  

LAB HEAD: Allan Stensballe

PROVIDER: PXD053348 | Pride | 2025-11-27

REPOSITORIES: Pride

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20220719_082953_E108D7g_full.sne Other
E108D7g_RA9_1_7748.d.rar Other
E10D7g_BD1_1_7696.d.rar Other
E11D7g_BD2_1_7697.d.rar Other
E12D14y_BD7_1_7702.d.rar Other
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Publications

Plasma amino acids after human milk fortification and associations with growth in preterm infants.

Rasmussen Martin Bo MB   Holgersen Kristine K   Muk Tik T   Leto Azra A   Stensballe Allan A   van Hall Gerrit G   Aunsholt Lise L   Kappel Susanne Soendergaard SS   Zachariassen Gitte G   Sangild Per Torp PT  

Pediatric research 20250518

<h4>Background</h4>It is unknown how plasma amino acid (AA) concentrations vary with fortification type, growth and insulin-like growth factor 1 (IGF-1) concentrations in the first weeks of life in very preterm infants (VPIs).<h4>Methods</h4>Human milk for VPIs (n = 225) was fortified with bovine colostrum (BC, intact proteins, high bioactivity) or conventional fortifier (CF, hydrolysed bovine whey proteins). Plasma was sampled at fortification start (T0, ~1 week of age) and after one (T1) and t  ...[more]

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