Sort   by:  
 Page size 
TranscriptomicsA Gene Expression Signature for Insulin Resistance
Insulin resistance is a heterogeneous disorder caused by a range of genetic and environmental factors, and we hypothesise that its aetiology varies considerably between individuals. This heterogeneity provides significant challenges to the development of effective therapeutic regimes for long-term m...
ORGANISM(S): Mus musculus 
2010-09-10 | E-GEOD-18103 | biostudies-arrayexpress
TranscriptomicsA Global Approach to Dissect Palmitate-induced Impairment of Hepatic Glucose Production
Obesity-induced insulin resistance of the liver is characterised by increased gluconeogenesis, which contributes to elevated blood glucose levels in individuals with type 2 diabetes. Research into how fatty acids induce insulin resistance has commonly focused on the induction of insulin resistance. ...
ORGANISM(S): Rattus norvegicus 
2013-11-08 | E-GEOD-52204 | biostudies-arrayexpress
TranscriptomicsHistone deacetylase inhibition replicates aspects of the adaptive response to exercise and improves muscle metabolism and cardiac function in obesity.
Drugs used to treat obesity and type 2 diabetes have limited efficacy in directly normalising muscle metabolism. The discovery of molecules mediating exercise adaptations, and drugs that modulate their activity, is a potential strategy to address this therapeutic gap. Here we show that genetic impai...
ORGANISM(S): Mus musculus 
2015-01-28 | E-GEOD-54642 | biostudies-arrayexpress
Sort   by:  
 Page size