Santos Andrea A

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Efficient DNA- and virus-free engineering of cellular transcriptomic states using dCas9 ribonucleoprotein (dRNP)-complexes

For genome editing, the use of CRISPR ribonucleoprotein (RNP) complexes is well established and often the superior choice over plasmid-based or viral strategies. RNPs containing dCas9 fusion proteins, which enable the targeted manipulation of transcriptomes and epigenomes remain significantly less a...

ORGANISM(S): Homo sapiens

2025-03-29 | GSE288075 | GEO

Circulating cell populations as response predictors and targets to improve immunotherapy in metastatic lung cancer

The effectiveness of immunotherapy varies among patients with advanced non-small cell lung cancer (NSCLC). Here we investigated the baseline immune status in stage IV NSCLC patients treated with anti-PD-1 plus chemotherapy to understand the immune mechanisms and unveil systemic markers associated...

2025-10-16 | MTBLS13150 | MetaboLights

Chromosome Y Philogeny in Sardinia

Genetic variation within the male specific portion of the Y chromosome (MSY) can clarify the origins of contemporary populations, but previous studies were hampered by partial genetic information. Population sequencing of 1,204 Sardinian males identified 11,763 MSY single nucleotide polymorphisms (S...

EGAS00001000532 | EGA

ena-DATASET-irgb_cnr-25-06-2013-12:35:10:789-8 - samples

1204 Sardinian males

EGAD00001000618 | EGA

Sardinian Chromosome Y DAC

Data Access Committee EGAC00001000121

EGAC00001000121 | EGA

New insertable cardiac monitors show high diagnostic yield and good safety profile in real-world clinical practice: results from the international prospective observational SMART Registry.

Not available

S-EPMC10227665 | biostudies-literature

Neutrophil/lymphocyte ratio and other blood cell component counts are not associated with the development of postmolar gestational trophoblastic neoplasia.

Not available