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MetabolomicsRepurposing the orphan drug nitisinone to control the transmission of African trypanosomiasis
Tsetse transmit African trypanosomiasis, which is a disease fatal to both humans and animals. A vaccine to protect against this disease does not exist so transmission control relies on eliminating tsetse populations. Although neurotoxic insecticides are the gold standard for insect control, they neg...
2021-10-06 | MTBLS2166 | MetaboLights
MetabolomicsSubcellular antibiotic visualization reveals a dynamic drug reservoir in infected macrophages
Tuberculosis, caused by the intracellular pathogen Mycobacterium tuberculosis, remains the world's deadliest infectious disease. Sterilizing chemotherapy requires at least 6 months of multidrug therapy. Difficulty visualizing the subcellular localization of antibiotics in infected host cells means t...
2020-12-07 | MTBLS959 | MetaboLights
MetabolomicsEpithelial-Cell-Derived Phospholipase A2 Group 1B Is an Endogenous Anthelmintic
Immunity to intestinal helminth infections has been well studied, but the mechanism of helminth killing prior to expulsion remains unclear. Here we identify epithelial-cell-derived phospholipase A2 group 1B (PLA2g1B) as a host-derived endogenous anthelmintic. PLA2g1B is elevated in resistant mice an...
2018-08-13 | MTBLS523 | MetaboLights
ProteomicsA novel TTBK2 missense variant causes loss of function and impaired protein phosphorylation: implications for spinocerebellar ataxia type 11
Spinocerebellar ataxia type 11 (SCA11) is a rare form of autosomal dominant cerebellar ataxia, characterized by a relatively slow progression and normal life expectancy. However, it is a highly debilitating disorder. In 2007, SCA11 was genetically linked to TTBK2, which encodes tau tubulin kinase 2 ...
ORGANISM(S): Homo sapiens (Human) 
2025-12-22 | PXD056662 | Pride
Spinocerebellar ataxia type 11 (sca11)  tau-tubulin kinase 2 (ttbk2)  crispr/cas9  kinase activity  phosphoproteomics  cytoskeleton 
MetabolomicsRhythmic glucose metabolism regulates the redox circadian clockwork in human red blood cells (LC-MS)

Circadian clocks coordinate mammalian behaviour and physiology enabling organisms to anticipate 24-hour cycles. Transcription-translation feedback loops are thought to drive these clocks in most of mammalian cells. However, red blood cells (RBCs), which do not contain a nucleus, and cannot perfor...

2020-11-13 | MTBLS1285 | MetaboLights
UnknownEffectiveness of HPV vaccination in reducing infection among young Brazilian women.
Not available
S-EPMC11749143 | biostudies-literature
TranscriptomicsExpression data from mesenchymal stromal cells isolated from the umbilical cord tissue (UCXM-BM-.) and cultivated in ATMP-compatible media
Standardization of MSC manufacturing is urgently needed to facilitate comparison of clinical trial results. Here, we compare gene expression of MSC generated by the adaptation of a proprietary method for isolation and cultivation of a specific umbilical cord tissue-derived population of Mesenchymal ...
ORGANISM(S): Homo sapiens 
2013-12-16 | E-GEOD-51869 | biostudies-arrayexpress
MetabolomicsRhythmic glucose metabolism regulates the redox circadian clockwork in human red blood cells (GC-MS)

Circadian clocks coordinate mammalian behaviour and physiology enabling organisms to anticipate 24-hour cycles. Transcription-translation feedback loops are thought to drive these clocks in most of mammalian cells. However, red blood cells (RBCs), which do not contain a nucleus, and cannot perfor...

2020-11-13 | MTBLS1286 | MetaboLights
ProteomicsVigna unguiculata CE31 roots quantitative control vs infected with Meloidogyne incognita vs drought vs cross-stress
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ORGANISM(S): Vigna Unguiculata (ncbitaxon:3917) 
2022-02-22 | MSV000088890 | MassIVE
ProteomicsVigna unguiculata CE31 aereal parts quantitative control vs infected with Meloidogyne incognita vs drought vs cross stress
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ORGANISM(S): Vigna Unguiculata (ncbitaxon:3917) 
2022-02-21 | MSV000088877 | MassIVE
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