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ProteomicsThrombocytopenia-associated mutations in MASTL deregulate global phosphorylation and actin cytoskeleton dynamics in platelets
MASTL, also known as Greatwall, was originally characterized in flies and Xenopus as a mitotic kinase involved in the maintenance of the mitotic state by inhibiting PP2A-B55 complexes. A specific mutation (E167D) in the human MASTL gene was simultaneously linked to autosomal dominant thrombocytopeni...
ORGANISM(S): Mus musculus (Mouse) 
2019-11-12 | PXD009398 | Pride
Platelets Kinase Cell cycle Mastl Phosphoproteomics 
TranscriptomicsExpression data from yeast (wild type, rlm1 and swi3 mutants) exposed to Congo Red
We did transcription profiling on the effect of rlm1 (MAPK Slt2 transcription factor) deletion and swi3 (component of SWI/SNF complex involved in chromatin remodeling) deletion in genes involved in cell wall stress (Congo Red) response. Three biological samples were analyzed for each condition, and ...
ORGANISM(S): Saccharomyces cerevisiae 
2012-05-24 | E-GEOD-31176 | biostudies-arrayexpress
UnknownUltrasonography effectiveness of the vibration vs cryotherapy added to an eccentric exercise protocol in patients with chronic mid-portion Achilles tendinopathy: A randomised clinical trial.
Not available
S-EPMC7948929 | biostudies-literature
UnknownEvidence for Ruthenium(II) Peralkene Complexes as Catalytic Species during the Isomerization of Terminal Alkenes in Solution.
Not available
S-EPMC10354743 | biostudies-literature
TranscriptomicsBisphosphonate related osteonecrosis of the jaw is associated with polymorphisms of the cytochrome P450 CYP2C8 in MM
We have explored the potential role of genetics in the development of osteonecrosis of the jaw (ONJ) in multiple myeloma (MM) patients under bisphosphonate therapy. A genome wide association study was performed using 500.568 single nucleotide polymorphisms (SNPs) in two series of homogeneously treat...
ORGANISM(S): Homo sapiens 
2008-09-25 | E-GEOD-11948 | biostudies-arrayexpress
ProteomicsA cell cycle kinase-phosphatase module restrains PI3K- Akt activity in an mTORC1-dependent manner
The AKT-mTOR pathway is a central regulator of cell growth and metabolism. Upon sustained mTOR activity, AKT activity is attenuated by a feedback loop that restrains upstream signaling. However, how cells control the signals that limit AKT activity is not fully understood. Here we show that MASTL/Gr...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-11-23 | PXD032796 | Pride
Mastl Phosphosites Mouse Human 
UnknownGEMA 5.3. Spanish Guideline on the Management of Asthma.
Not available
S-EPMC10598226 | biostudies-literature
UnknownChanges in the immune response against SARS-CoV-2 in individuals with severe COVID-19 treated with high dose of vitamin D.
Not available
S-EPMC9008199 | biostudies-literature
UnknownOccurrence of SARS-CoV-2 viremia is associated with genetic variants of genes related to COVID-19 pathogenesis.
Not available
S-EPMC10557488 | biostudies-literature
UnknownHeterogeneity in the association between prediabetes categories and reduction on glomerular filtration rate in a 5-year follow-up.
Not available
S-EPMC9072306 | biostudies-literature
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