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TranscriptomicsComparative expression data from HBVP (human brain vascular pericytes) and human MSC (mesenchymal stem cells)
Pericytes and mesenchymal stem cells (MSC) are ontogenically related, and in fact no phenotypic differences were observed by flow cytometry using a panel of surface antigen markers. Global gene expression profiles of human pericytes and MSC revealed that 43 genes were expressed more than 10 fold in ...
ORGANISM(S): Homo sapiens 
2013-12-04 | E-GEOD-46235 | biostudies-arrayexpress
TranscriptomicsGenome-wide expression profiling of B Lymphocytes reveals IL4R increase in allergic asthma
In this study we present the first genome-wide expression profiling of peripheral B cells by massive parallel RNA sequencing in patients with allergic asthma validating the discovery potential of this approach in allergy. RNA-seq was used to asses expression differences in B CD19 Lymphocytes from ho...
ORGANISM(S): Homo sapiens 
2014-08-28 | E-GEOD-52742 | biostudies-arrayexpress
TranscriptomicsExpression data from LPS-treated HBVP (human brain vascular pericytes)
Identification of TLR4 as one of the most abundant RNA species in pericytes with respect to MSC, and corroboration of TLR4 expression on the cell surface, led us to obtain a comprehensive overview of the expression program of lipopolysaccharide (LPS) stimulated pericytes. Microarray analyisis demons...
ORGANISM(S): Homo sapiens 
2013-12-04 | E-GEOD-46236 | biostudies-arrayexpress
ProteomicsMouse WAT mitochondrial bioenergetics LC-MSMS
Whether muscle mitochondrial dysfunction is the cause or consequence of metabolic disorders remains controversial. Herein, we demonstrate that inhibition of mitochondrial ATP synthase in muscle in vivo alters whole-body lipid homeostasis. Mice with restrained activity of the enzyme presented intrafi...
ORGANISM(S): Mus musculus (Mouse) 
2020-07-06 | PXD017678 | Pride
Mouse wat 
ProteomicsSkeletal Muscle from Mice fed with HFD LC-MSMS
Whether muscle mitochondrial dysfunction is the cause or consequence of metabolic disorders remains controversial. Herein, we demonstrate that inhibition of mitochondrial ATP synthase in muscle in vivo alters whole-body lipid homeostasis. Mice with restrained activity of the enzyme presented intrafi...
ORGANISM(S): Mus musculus (Mouse) 
2020-07-06 | PXD017683 | Pride
Mouse skeletal muscle hfd 
ProteomicsMouse Skeletal Muscle mitochondrial bioenergetics LC-MSMS
Whether muscle mitochondrial dysfunction is the cause or consequence of metabolic disorders remains controversial. Herein, we demonstrate that inhibition of mitochondrial ATP synthase in muscle in vivo alters whole-body lipid homeostasis. Mice with restrained activity of the enzyme presented intrafi...
ORGANISM(S): Mus musculus (Mouse) 
2020-07-06 | PXD017621 | Pride
Mouse skeletal muscle 
TranscriptomicsBisphosphonate related osteonecrosis of the jaw is associated with polymorphisms of the cytochrome P450 CYP2C8 in MM
We have explored the potential role of genetics in the development of osteonecrosis of the jaw (ONJ) in multiple myeloma (MM) patients under bisphosphonate therapy. A genome wide association study was performed using 500.568 single nucleotide polymorphisms (SNPs) in two series of homogeneously treat...
ORGANISM(S): Homo sapiens 
2008-09-25 | E-GEOD-11948 | biostudies-arrayexpress
TranscriptomicsPhenotypic, genomic and functional characterization reveals no differences between CD138++ and CD138low subpopulations in multiple myeloma cell lines (Copy Number)
Despite recent advances in the treatment of multiple myeloma (MM), it remains an incurable disease potentially due to the presence of resistant myeloma cancer stem cells (MM-CSC). Although the presence of clonogenic cells in MM was described more than 30 years ago, the phenotype of MM-CSC is still a...
ORGANISM(S): Homo sapiens 
2014-05-19 | E-GEOD-49483 | biostudies-arrayexpress
TranscriptomicsPhenotypic, genomic and functional characterization reveals no differences between CD138++ and CD138low subpopulations in multiple myeloma cell lines
Despite recent advances in the treatment of multiple myeloma (MM), it remains an incurable disease potentially due to the presence of resistant myeloma cancer stem cells (MM-CSC). Although the presence of clonogenic cells in MM was described more than 30 years ago, the phenotype of MM-CSC is still a...
ORGANISM(S): Homo sapiens 
2014-05-19 | E-GEOD-49482 | biostudies-arrayexpress
UnknownGuidelines for the use of flow cytometry and cell sorting in immunological studies (second edition).
Not available
S-EPMC7350392 | biostudies-literature
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